New IBM CHRO Study: AI Puts Critical Thinking at the Center of Workforce Priorities
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- 60% of employees worry AI is eroding their skills, with critical thinking cited most often as declining

- Nearly half of organizations do not involve the CHRO when AI strategy is being defined

ARMONK, N.Y., Sept. 21, 2026 /PRNewswire/ -- A new global study from the IBM (NYSE: IBM) Institute for Business Value points to a disconnect between the skills Chief Human Resource Officers (CHROs) say AI requires and those employees prioritize. While 71% of CHROs identify the ability to supervise, validate and override AI outputs as the workforce's most essential skill, only 29% of employees rank judgment as important.

The study,* which surveyed 1,500 CHROs and 8,800 employees globally, finds that 60% of employees worry about skills erosion, with critical thinking cited most often as declining. At the same time, CHROs identify critical thinking (57%) and human judgment (48%) as among the workforce's most important capabilities.

The findings also show that organizations creating the greatest value from AI are redesigning work, decision-making and workforce capabilities around people and technology. Organizations that clearly define workflows as human-led, AI-assisted or AI-executed report achieving 18% risk reduction and 20% quality improvement. Yet, nearly half (46%) of organizations do not involve the CHRO when AI strategy is being defined.

"AI is changing not only how work gets done, but where people can contribute the greatest value," said Nickle LaMoreaux, Senior Vice President and Chief Human Resources Officer, IBM. "As AI takes on more routine and process-driven tasks, uniquely human capabilities become even more important. CHROs have a critical role to play in redesigning the workplace of the future so people can focus on the areas where they can have the greatest impact."

Other key findings from the study include:

Concerns about skills erosion reinforce the importance of judgment and critical thinking

- Among employees who worry about skills erosion, three out of four say AI has already begun to erode at least some of their skills.

- Skills erosion ranks among CHROs' top concerns, cited by 46% of respondents.

- 49% of employees and 57% of CHROs say critical thinking and problem framing are among the skills that matter most in the AI era.

- Where judgment is built into how work is done, 62% of CHROs report growing employee confidence in AI-enabled decisions; where it is not, 57% report confidence declining.

AI accountability gaps are impacting employees

- 43% of employees report that when something goes wrong with AI, the blame falls on them, while 41% of CHROs believe employees may not feel safe challenging or overriding AI outputs.

- 36% of CHROs say unclear accountability complicates AI deployment.

- Only 28% of CHROs report a joint roadmap with IT backed by a shared operating cadence, and 73% say they struggle to coordinate consistently across the C-suite.

- Where the CHRO at least shares responsibility for which decisions remain human-led, 76% of employees feel safe to question or override AI recommendations, compared with 43% where HR is merely advisory.

AI gains are creating new pressure on the workforce

- 80% of CHROs believe AI adoption creates "invisible" work for employees, including validating recommendations, fixing mistakes, providing context and managing exceptions.

- 42% of employees say AI increases their work or their work goes unrecognized.

- 42% of CHROs say AI productivity gains are primarily reinvested for innovation or reskilling.

HR is expected to lead AI transformation, but its own adoption lags

- 72% of organizations make limited or no use of AI inside the HR function.

- CHROs rate HR's capabilities particularly low in AI literacy across the team (13%), AI performance measurement (16%) and change management for AI adoption (20%).

- Organizations with mature HR AI capability, including governance, architecture and measurement, are nearly twice as likely to report a higher number of positive business KPIs.

To view the full study, visit: https://www.ibm.com/thought-leadership/institute-business-value/en-us/c-suite-study/chro

The study also features perspectives from CHROs and people leaders on how organizations are responding to AI-driven changes in the workforce. A selection of these firsthand views is available in the addendum below.

*Study Methodology:

The IBM Institute for Business Value, in collaboration with Oxford Economics, conducted two complementary surveys from April to June 2026. The first survey gathered insights from 1,500 CHROs and equivalent senior executives responsible for workforce strategy on how they design work, culture and the workforce for an AI-enabled enterprise across 21 geographies and 23 industries. Executive respondents represented organizations of varying sizes and sectors, from $250 million USD to $123.7 billion USD in annual revenue or budget and from 200 to more than 880,000 employees. The second survey polled 8,800 full-time employees spanning 28 countries to capture their experience with AI at work. Additional analysis was conducted to identify organizations converting AI into growth versus those converting it into savings, segmenting organizations by strategic maturity based on capabilities and culture readiness.

The IBM Institute for Business Value, IBM's thought leadership think tank, combines global research and performance data with expertise from industry thinkers and leading academics to deliver insights that help business leaders make informed decisions. For more information, visit www.ibm.com/ibv. To receive more insights, subscribe to the IdeaWatch newsletter: https://ibm.co/ibv-ideawatch.

About IBM

IBM is a leading provider of global hybrid cloud and AI, and consulting expertise. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Thousands of governments and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM's hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM's breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and consulting deliver open and flexible options to our clients. All of this is backed by IBM's long-standing commitment to trust, transparency, responsibility, inclusivity and service. Visit www.ibm.com for more information.

Media contact:

Marisa Conway

IBM Corporate Communications

[email protected]

Estefania Sanchez

IBM Corporate Communications

[email protected] 

Executive perspectives:

"Fluency without judgment simply helps an organization make mistakes faster." – Dr. Amit Das, Director and CHRO, Bennett Coleman & Co. Ltd. (The Times of India)

"Rather than asking how much work was completed, we're asking whether AI helped improve decision quality, speed, employee experience, guest satisfaction and business performance." – Kristin Oliver, Chief Human Resources Officer, Hyatt Hotels Corporation

"An AI-enabled culture that is grounded in the principle that humans are any company's secret sauce will differentiate you versus competitors. AI is a tool for humans to perform their best work." – Cecilia McKenney, Senior Vice President & CHRO, Quest Diagnostics

"Offering an organization a design framework for transformation is HR work. It's actually the HR work everyone aspires to." – geneviève bich, Vice President - Human Resources (CHRO) and Board member, Metro

"We think of the CHRO and CTO as the power couple because they are bringing talent strategy and technology strategy into one conversation. Together, we're co-architects of the work." Ali Peek Bebo, CHRO, Pearson

SOURCE IBM

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<p>60% of employees worry AI is eroding their skills, with critical thinking cited most often as declining Nearly half of organizations do not involve the CHRO when AI strategy is being defined ARMONK, N.Y., Sept. 21, 2026 /PRNewswire/ -- A new global study from the IBM (NYSE: IBM) Institute...</p>

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Envision Energy Powers Morocco's First Large-Scale Battery Storage System at OCP's Benguerir Mining Site
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Envision Energy Powers Morocco's First Large-Scale Battery Storage System at OCP's Benguerir Mining Site

BENGUERIR, Morocco, Sept. 21, 2026 /PRNewswire/ -- Envision Energy, a global leader in green technology, today announced the successful energisation of Morocco's first large-scale lithium iron phosphate (LFP) battery energy storage system at OCP Green Energy's Benguerir mining site. The 25 MW / 125 MWh system was supplied and commissioned by Envision Energy under a contract signed in late 2025, and is now undergoing testing before entering commercial operation.

Envision Energy provided the full storage system and led the commissioning work, integrating the BESS with the site's solar generation, grid conditions and industrial load profile. The system is designed to shift surplus solar power from daytime generation to peak consumption hours, reducing the site's peak-hour electricity bill by approximately 25%.

With five hours of storage capacity, the BESS functions as an industrial energy management tool rather than a short-duration grid asset. It is supported by USD 20 million from the Clean Technology Fund, managed through the African Development Bank Group, and is designed for a 25-year lifetime with daily charge-discharge cycles. For OCP, the value lies not in battery capacity, but in the system's ability to reduce peak-hour costs over a 25-year operating life.

"The successful energisation of Morocco's first large-scale battery storage project demonstrates the reliability, flexibility and cost-effectiveness of integrated renewable-plus-storage solutions in industrial applications," said John Lee, General Manager of Envision Energy for the Middle East and Africa. "Envision is proud to be part of this landmark project and to contribute green technology to Morocco's energy transition."

As highlighted in OCP Group's official press release announcing the milestone, Omar Kadir, CEO of OCP Green Energy, said: Storage is the natural extension of our energy strategy. It allows us to reconcile the variable output of renewable energy with the continuous needs of our industrial platforms, while strengthening the reliability of our energy supply. Beyond OCP Group's own needs, this technology paves the way for a more harmonious integration of renewable energy into the national power system. By bringing greater flexibility and resilience to the grid, it will help accelerate the deployment of renewable capacity."

The project marks a significant milestone for battery storage and industrial decarbonisation in Morocco. It supports the country's target of achieving 52% of installed electricity capacity from renewable sources by 2030 and serves as a benchmark for industrial decarbonisation across Africa.

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<p>BENGUERIR, Morocco, Sept. 21, 2026 /PRNewswire/ -- Envision Energy, a global leader in green technology, today announced the successful energisation of Morocco's first large-scale lithium iron phosphate (LFP) battery energy storage system at OCP Green Energy's Benguerir mining site. The...</p>

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Global Times: Two generations of an American family forge a century-long connection with a town in Northwest China through medicine, memories and enduring affection
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Global Times: Two generations of an American family forge a century-long connection with a town in Northwest China through medicine, memories and enduring affection

HUANGYUAN, China, Sept. 20, 2026 /PRNewswire/ -- Across two generations of an American family, Victor G. Plymire put down roots in Huangyuan, Northwest China's Qinghai Province, for nearly 30 years; his daughter Mary Ann Plymire's final wish was to be laid to rest in Huangyuan; and his son David V. Plymire regarded Huangyuan as his only hometown and raised funds to donate medical equipment worth more than 6 million yuan (about $895,000).

On September 10, across the Pacific in Springfield, Missouri, the US, 95-year-old David V. Plymire sat at home and opened the photo album Imprints. In a panoramic photograph of Dan Gar Ancient Town in Huangyuan taken in 1942, six children stood on a hillside.

"This is me. I was in my teens then. 'Nao' [I] will always be a kid from Huangyuan," David said in an authentic Huangyuan dialect during a video conversation, pointing at the photograph.

At the other end of the screen was Huangyuan in Qinghai. Wang Shikang, former president of Huangyuan County People's Hospital, called out in the Huangyuan dialect, "Brother David, we've got hand-grabbed mutton ready for you."

Across the screen, David's eyes reddened slightly and his voice trembled a little. "Whenever I have a moment, I miss everyone," he said.

Li Lin, former director of the Huangyuan County Health Bureau, also leaned toward the camera. "Mr Plymire, we haven't seen you for more than 10 years. None of us can forget you."

In Huangyuan, Mr "Big Nose" is well known. "The big-nosed American loves Chinese niangpizi (a local cold snack). He adds chili and vinegar, and gets chili all over his nose…" Wang recited a nursery rhyme that people in Huangyuan still sing today. Hearing it, "Big Nose" David laughed.

Why did an American born in New York find his way into a Huangyuan nursery rhyme? The answer begins with a story spanning more than a century, in which two generations of an American family forged ties with China.

Roots in Huangyuan

In 1932, just after turning one year old, David crossed the ocean with his father, Victor, and arrived in Huangyuan in Qinghai. Victor had first come to China in 1908, living in places including Gansu Province and Qinghai before making his home in Huangyuan.

In the eyes of Huangyuan residents, Victor was "one of our family." Modest and sincere, he respected the customs of local ethnic groups, worked hard to learn Chinese and the Tibetan language, and used his knowledge of Western medicine to provide free diagnosis and treatment to people of different ethnic groups.

Entering the clinic Victor once operated, one can lift a concealed door in the floor and descend a steep, narrow wooden ladder into the basement. Overhead are thick log beams bearing marks left by axes and chisels. Blue-brick walls surround the space, with only a small ventilation window.

During bandit unrest before the founding of the People's Republic of China in 1949, it was here that Victor helped innocent Huangyuan residents withstand the turmoil.

David spent more than a decade in Huangyuan from young adulthood. Every plant and tree there felt dear and familiar to him. Later, he reluctantly left Huangyuan with his family. He subsequently lived for more than 30 years in places including China's Hong Kong, before eventually settling in the US state of Missouri.

For David, the eastern foothills of the Qinghai-Xizang Plateau and the headwaters of the Huangshui River were his only hometown. The longer he was away, the deeper his longing became. To keep his accent of Huangyuan local dialect from fading, he would talk to himself in front of a mirror every day, "otherwise, after enough time, I would forget it."

Giving back to his hometown

In 1987, after 38 years away, David finally set foot in Huangyuan again. Asked by reporters how he had felt when he returned that year, David was silent for a moment before saying, "Before I came back, it had been almost 40 years since I had seen my hometown or my family."

He found his childhood friend Qin Cizhe, and both were deeply emotional when they met. David stepped into the old house where he had once lived, his eyes filled with tears. Seeing his former neighbors and friends, and the streets and lanes he had dreamed of for decades, the homesickness buried deep in his heart immediately turned into action.

He wanted to do something practical for his hometown. Li recalled, "He visited many places and first turned his attention to hospitals that were desperately short of advanced equipment."

In March 1989, David and his sister Mary Ann bought an ultrasound scanner in Hong Kong for HK$150,000 (about $19,100), at a time when such equipment was among the items most urgently needed by county-level hospitals.

How did they bring it back? There were no express delivery or logistics services available to them. David carried the machine by plane from Hong Kong to Xi'an, Shaanxi Province and then from Xi'an to Huangyuan.

From that day on, he never stopped.

Wang first came into contact with David in 1988. The two exchanged dozens of letters and became close friends. Over the following more than 30 plus years, David traveled between the US and Huangyuan more than 20 times.

In letters to Wang, David mentioned more than once that he had managed to save some money. In one letter, he wrote that he had more than $8,000 on hand, saying, "It isn't doing much good sitting here with me. It would be better to donate it to the hospital and use it where it is needed."

Wang said, "He was not actually wealthy. Every cent came from friends, foundations and other sources. He was putting the money into Huangyuan."

In 1999, David ordered a CT scanner worth $350,000 for Huangyuan County Hospital. At the time, it could be considered a "luxury." "We badly needed one, but we knew it was too expensive and felt embarrassed to ask," Li said.

After David learned what they were thinking, he found himself in a difficult position, but after returning home he still worked hard to make it happen. "The money had originally been intended as a donation elsewhere. He persuaded the people at the foundation, and in the end it was donated to Huangyuan."

David made three trips, and in June 2000 the CT scanner arrived in Huangyuan. The People's Hospital of Huangyuan became one of the few county-level medical institutions in Qinghai Province to have a CT scanner at the time.

After the CT scanner arrived, David bowed deeply to the machine and said in the most authentic Huangyuan dialect, "This CT scanner must serve the people of my hometown well."

"Every time I see that photograph, I become inexplicably emotional and feel like crying. What he did was not easy - it was extraordinarily difficult!" said Huang Jiong, the current president of Huangyuan County People's Hospital.

Li remembered accompanying David on one occasion to several township health centers in rural areas. "Conditions at township health centers were poor at the time. If local people had even a minor ailment, they had to travel to the county seat or even the provincial capital for an examination. Not only was it a long journey, it was also expensive. David was distressed by what he saw," Li recalled. "Without hesitation, he found a way to raise $10,000, bought four ultrasound machines and distributed them to four township health centers."

With the ultrasound machines, doctors at the health centers could carry out basic examinations. Common conditions such as cholecystitis and gallstones could be detected locally, and patients whose results indicated a problem could then be referred to the county hospital. Li said, "The equipment may have been small, but it made a huge difference at the grassroots level."

Statistics show that medical equipment donated to Huangyuan county by David, his family and friends was worth more than 6 million yuan. The list included ultrasound machines, gastroscopes, ECG monitors, fully automated blood cell counters and anesthesia machines, among others. During the video call, Huang told David that the hospital now receives 300,000 outpatient visits a year, while Huangyuan county has a population of only a little more than 100,000. "Behind this are your tremendous efforts and selfless dedication," Huang told him.

During the video link, a reporter asked David, "What has sustained you and kept you doing this all these years?"

David replied, "There is a feeling in my heart that I simply have to do it, because these are all my family. Some people say I have made a great contribution to my hometown. I say that what you do for your hometown cannot be regarded as a contribution. It is our duty. You cannot simply not do it. It is only natural."

At one donation ceremony, he said sincerely, "What I do for Huangyuan county hospital is simply fulfilling my duty to my own family. Please, I beg you, don't use the word 'contribution' anymore."

What David brought to Huangyuan went beyond medical equipment.

David said he received his earliest education in Huangyuan and understood deeply what knowledge meant to children on the plateau. He worked through various channels to arrange for foreign teachers to come to Huangyuan and provide training for primary and secondary school English teachers.

Always 'in my heart'

Victor was an accomplished photographer who took hundreds of photographs documenting the social life and landscapes of Gansu, Qinghai and Xizang at the time, leaving behind precious historical visual records. David gradually donated hundreds of his father's valuable old photographs to Huangyuan county. Using the photographs as a foundation, Huangyuan county organized experts and scholars to compile and publish the photo album Imprints. The album was included in national archival records, filling a gap in Huangyuan county's historical photographic archives.

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QA FAIL (need review): TARGET states David V. Plymire 'funded' the $350,000 CT scanner and attributes the entire 6 million yuan equipment donation to Huangyuan County People's Hospital; SOURCE says the CT scanner was paid for via a foundation donation that David persuaded to be redirected, and the equipment total was donated to Huangyuan county at large, including township health centers.
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<p>HUANGYUAN, China, Sept. 20, 2026 /PRNewswire/ -- Across two generations of an American family, Victor G. Plymire put down roots in Huangyuan, Northwest China's Qinghai Province, for nearly 30 years; his daughter Mary Ann Plymire's final wish was to be laid to rest in Huangyuan; and his...</p>

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Reap Launches First Ever Managed Fraud and Risk Service for Card Programs
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Reap Launches First Ever Managed Fraud and Risk Service for Card Programs

Reap Sentry configures and manages fraud controls for clients' card programs, eliminating the need for additional monitoring tools or in-house fraud specialists.

HONG KONG, Sept. 20, 2026 /PRNewswire/ -- Reap, a global financial technology company that enables financial connectivity and access for businesses worldwide through stablecoin-enabled infrastructure, today announced the launch of Reap Sentry, a managed card fraud and risk service. Through Sentry, Reap manages a client's end-to-end transaction risk management - from configuring fraud rules and screening authorisations in real time to investigating alerts, processing chargebacks, and reporting confirmed fraud to Visa. Clients do not need to build or license additional fraud-monitoring tools, or hire a dedicated fraud team.

Payment card fraud losses worldwide totalled USD 33.41 billion in 2024 (The Nilson Report, January 2026), tied to global card volume of USD 51.920 trillion (The Nilson Report, January 2026). Every card in circulation is a live payment instrument, with authorisation decisions made in milliseconds. Fraud must be stopped at the point of authorisation, not afterwards, as the knock-on costs of fraud can often exceed the value of the fraud itself. Meanwhile, evolving attack patterns make fraud management an ongoing operational function.

Built on the technology within Reap's issuing portfolio, Sentry combines the fraud policy, tooling, and day-to-day operations required to manage transaction risk effectively. Having issued millions of cards over eight years of card issuance, Reap brings to Sentry controls informed by fraud patterns observed across its entire issuing portfolio. These controls are tailored to each client's business profile, including its cardholder segments, geographic footprint, and stated risk appetite.

Sentry conducts ongoing screening and declines suspected fraud in real time at authorisation; triages and investigates alerts; and continuously updates controls as new threats emerge, including BIN attacks and merchant breaches. The service also processes and represents chargebacks submitted by clients, reports confirmed fraud, and provides program performance reporting on an agreed cadence. Controls are reviewed and refined as each program evolves, without requiring client intervention. Clients can integrate with Sentry through a single Reap API.

Reap protects the authorisation layer it operates and observes, while clients retain responsibility for the cardholder relationship and key first-party fraud entry points, including onboarding, identity verification and account access.

"Most companies launching a card programme have to build a fraud function from day one. Doing so requires specialist tooling, dedicated expertise and several months of preparation before they can safely issue a single card, by which point the threat landscape may already have shifted. That is rarely how a team wants its first months to go." said Harris Leow, Head of Product, Reap. "Sentry takes on that entire card fraud function: our controls, data and specialists, tailored to each card programme."

Sentry is available to new Reap card issuing clients and to existing clients at contract renewal, on Reap's own API.

To find out more about Sentry, visit our website: https://reap.global/products/sentry-fraud-risk-management

About Reap

Reap is a global financial technology company that enables financial connectivity and access for businesses worldwide through stablecoin-enabled infrastructure. We transform the financial landscape through more efficient money movement by merging traditional finance with digital assets, bridging disparate economies and connecting key financial markets.

Reap was an early leader in Asia to incorporate stablecoins into our solutions. In 2025, Reap processed billions in stablecoin-funded transaction flows. From stablecoin-enabled corporate cards to cross-border payments, we streamline financial operations and empower companies to scale with our integrated business accounts and embedded finance solutions.

Founded and headquartered in Hong Kong, Reap employs 300 people worldwide. More information about Reap can be found at reap.global.

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Golden Week 2026 Fuels Extended Breaks and New Travel Routes: Trip.com Group Reveals Rising Destinations and Regional Trends
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Outbound departures peak before official Golden Week holidays, as Chinese travellers seek respite with nature escapes and cultural exploration

Seoul ranks as the top overseas holiday destination globally, with 91% YoY increase in flight bookings made

SINGAPORE, Sept. 20, 2026 /PRNewswire/ -- Chinese travellers are gearing up for one of the busiest travel periods, as Trip.com Group's latest data reveals earlier departures and longer trips planned this Golden Week. By taking three days off this year, workers can extend their holiday into a 13-day break, combining their Golden Week and Mid-Autumn Festival holidays into one. Outbound departures are expected to spike as early as September 25th, with an average trip length of over nine days.

With the Mid-Autumn Festival landing the Friday before the Golden Week holidays in October this year, Chinese travellers are shifting their vacations earlier to avoid the holiday rush. More than half of the outbound flight bookings made are for departures before the official holiday begins on October 1st, with daily departure volume peaks on September 25th and 30th.

Chinese tourists are not just departing earlier, they are also making use of the extended break to take longer and further trips beyond the region. Bookings for hotel stays of seven nights and more are seeing a year-on-year (YoY) jump of 123%, and even faster growth is seen for bookings in major European cities like London and Paris. Similarly, long-haul flight bookings are set to see double-digit YoY growth, with demand concentrating among gateway cities in Europe, Australia and the United States.

One Trip, Multiple Destinations

As Chinese travellers venture further, multi-destination trips are experiencing a surge in demand. Bookings for multi-destination itineraries have risen by 84% YoY, reflecting a growing trend to maximise long-haul travel across multiple cities. Southeast Asia and Europe are some of the top destinations for multi-stop journeys, and popular combinations include Singapore - Bali (Southeast Asia), Hong Kong - Sydney, and Amsterdam - Milan (Europe)[1].

Rising Hotspots: Nature Escapes and Cultural Heritage Immersion

Mountain landscapes and coastal retreats are where Chinese audiences are headed to this Golden Week, with searches for "scenic trips" and "nature getaways" up by 53% YoY. Coastal and high-altitude cities, including Qingdao, Lhasa and Kashgar, are among the fastest-growing domestic holiday destinations by flight, while mountainous areas like Xiangxi, Zhangjiajie, and Guilin are rapidly gaining popularity among domestic rail travellers.

Meanwhile, island holidays are in high demand among outbound Chinese travellers, with Jeju and Bali ranking among the top 10 most booked flight destinations. Popular beach destinations in Southeast Asia are also seeing a sharp rise in interest from Chinese visitors, with YoY flight bookings to Cebu and Phuket up by 111% and 78% respectively. Europe is a popular choice for long-haul vacations, with cultural hotspots like Brussels and Athens seeing significant increases in YoY flight bookings this year.

Millennials and Gen Zs are leading this trend, with those aged 18 to 24 showing the highest YoY growth in bookings across age groups. Known for its natural landscapes, New Zealand is an emerging destination among Gen Z travellers, with Queenstown and Auckland capturing a YoY rise in flight bookings of 314% and 276% respectively. Secondary cities, including Incheon and Chiang Mai, are also growing rapidly in popularity among this age group[2].

Inbound Tourism Growth as Asia Celebrates Mid-Autumn

With the Mid-Autumn Festival widely celebrated across Asia, and China's growing appeal among international travellers, inbound tourism is showing strong signs of growth.

Lesser-known Chinese cities such as Yanji, Dunhuang and Hailar are experiencing some of the fastest increases in flight bookings, while major cities like Shanghai, Beijing and Guangzhou continue to attract strong inbound travel flows, popular with visitors from Hong Kong SAR, South Korea, Singapore, Malaysia, as well as Australia.

With its rich cultural heritage and myriad attractions, China is fast becoming a popular holiday destination across all ages. One of the top-booked attractions among overseas visitors this Golden Week is the Mutianyu Great Wall, which travellers can experience via Trip.com's free layover tour, Beijing Express. Launched in December 2024, the tour offers international travellers with over 8 hours of layover time to explore Beijing's top attractions, including Mutianyu Great Wall, Temple of Heaven and Tiananmen Square. Based on Trip.com's Express Tours latest data, Mutianyu Great Wall route accounts for more than half of all Beijing Express bookings, and is the most popular choice among overseas visitors during the extended Golden Week holidays. Other popular attractions include the Shanghai Disney Resort, Emperor Qinshihuang's Mausoleum Site Museum and Zhangjiajie National Forest Park, all ranked on Trip.Best's 2026 global list of recommendations on 'Best Things to Do'[3].

Long Holidays Drive Intra-Asia Travel

Globally, Seoul ranks as the top holiday destination during Golden Week this year, with 91% YoY growth in international flight bookings. Beyond the bustling capital, global flight bookings to Busan, Cheongju and Daegu are also showing three-digit YoY growth, revealing South Korea's multifaceted appeal as a travel destination. Meanwhile, Japan remains a popular destination for many Asian travellers, including those from Malaysia, Thailand and South Korea[4].

This year's Mid-Autumn Festival also coincides with one of the most important holidays in South Korea, Chuseok, fuelling further travel exchanges within the region. Similar to Chinese tourists, South Korean travellers can extend their Chuseok holiday by taking three days off (September 19-27), and Trip.com Group's data shows that this is driving travel growth, with flight bookings to Fukuoka and Shanghai seeing YoY increases of 70% and 68% respectively. Japanese and Chinese travellers are the primary drivers of this travel growth, highlighting strong exchanges in demand within the region[5].

Together, these patterns reflect robust travel growth across Asia, boosted by long and overlapping holidays.

Trip.com Group is a global travel service provider comprising of Trip.com, Ctrip, Skyscanner, and Qunar. Across its platforms, Trip.com Group helps travellers around the world make informed and cost-effective bookings for travel products and services and enables partners to connect their offerings with users through the aggregation of travel-related content and resources, and an advanced transaction platform consisting of apps, websites and 24/7 customer service centres. Founded in 1999 and listed on NASDAQ in 2003 and HKEX in 2021, Trip.com Group is on the mission "to pursue the perfect trip for a better world". Find out more about Trip.com Group here: group.trip.com.

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<p>Outbound departures peak before official Golden Week holidays, as Chinese travellers seek respite with nature escapes and cultural exploration Seoul ranks as the top overseas holiday destination globally, with 91% YoY increase in flight bookings made SINGAPORE, Sept. 20, 2026 /PRNewswire/...</p>

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Solidion Technology Board Appoints Jaymes Winters as Chairman and CEO; Mark Schwartz as Lead Independent Director
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New Designations Designed to Strengthen Leadership Structure to Advance Strategic Priorities and Execution

DALLAS, Sept. 20, 2026 /PRNewswire/ -- Solidion Technology, Inc. (NASDAQ: STI) ("Solidion Technology" or "the Company"), an advanced battery technology solutions provider, today announced an update to the leadership structure of its Board of Directors (the "Board"), designed to further align the Company's governance with its strategic direction and business priorities.

Appointment of Jaymes Winters as Chairman & Chief Executive Officer

Additionally, effective September 16, 2026, the Board has appointed Chief Executive Officer Jaymes Winters to also serve as Chairman of the Board, effective immediately. Mr. Winters will continue to serve as Chief Executive Officer, assuming the combined role of Chairman and CEO. Mr. Winters brings more than 15 years of experience as a Chief Executive across the oil and gas, telecommunications and retail sectors, with extensive experience in mergers and acquisitions. Prior to Solidion, he served as CEO of Nubia Brand International Corp, a Special Purpose Acquisition Company and previously founded and served as CEO of United Energy Inc., which grew to nearly $100m in revenue under his leadership. Mr. Winters directed and negotiated significant M&A transactions involving private equity firms and previously served for more than 9 years as an adjunct professor in the School of Business at Portland State University, where he taught business strategy, mergers and acquisitions and venture capital. He holds a B.S. in Business Administration with a minor in Economics from Oregon State University.

"Solidion is entering an important stage in its development, and we believe this leadership structure provides the Company with the alignment and accountability necessary to execute on our strategic priorities," said Mark Schwartz, Lead Independent Director.

The Board believes the updated leadership structure will further centralize and align Solidion's strategic direction, corporate governance and business operations. Combining the Chairman and CEO roles is intended to provide greater continuity between the Company's strategic priorities and their execution, while appointment of a Lead Independent Director maintains a strong independent voice within the Board's leadership structure.

The Board also expressed its appreciation to Dr. Bor Jang for his longstanding service and leadership as former Chairman of the Board, and for his significant contributions to Solidion Technology. Dr. Jang has played an important role in the development of the Company and its extensive intellectual property and technology portfolio. Solidion is grateful for Dr. Jang's years of leadership and contributions to the Company. Dr. Jang remains a valued Director on the Board.

Election of Mark N. Schwartz as the Lead Independent Director

The Board has appointed independent director Mark N. Schwartz to serve as Lead Independent Director, effective September 16, 2026. In this role, Mr. Schwartz will help facilitate strong independent oversight of the Company while working closely with the Chairman and other members of the Board. Mr. Schwartz is an accomplished CEO, CFO and board director with more than 36 years of leadership experience across the consumer, technology and healthcare sectors. He co-founded Bodega Latina Corporation, which grew into a multibillion-dollar grocery business and the largest Hispanic retailer in the United States, led the IPO of DD Group plc and oversaw the sale of Bartell Drug Company to Rite Aid. Mr. Schwartz has served on more than a dozen public and private company boards, including Starbucks Coffee Company. He received a Bachelor of Arts, cum laude, from Claremont McKenna College in economics and political science and a Master of Business Administration, with honors, from Harvard Business School.

"Mark's extensive executive and board leadership will provide an important independent perspective as we continue to strengthen our governance and position Solidion for its next phase of growth," said Jaymes Winters, Chief Executive Officer of Solidion.

About Solidion Technology, Inc.

Headquartered in Dallas, Texas with pilot production facilities in Dayton, Ohio, Solidion's (NASDAQ: STI) core business includes manufacturing of battery materials and components, as well as development and production of next-generation batteries for energy storage systems, including UPS systems serving the artificial intelligence (AI) data center market and electric vehicles for ground, aerospace, and sea transportation. Solidion holds a portfolio of over 385 patents, covering innovations such as high-capacity, silane gas free and graphene-enabled silicon anodes, biomass-based graphite, advanced lithium-sulfur and lithium-metal technologies.

For more information, please visit www.solidiontech.com or contact Investor Relations.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Solidion Technology Inc., (NASDAQ: STI) (the "Company," "Solidion," "we," "our" or "us") desires to take advantage of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and is including this cautionary statement in connection with this safe harbor legislation. The words "forecasts" "believe," "may," "estimate," "continue," "anticipate," "intend," "should," "plan," "could," "target," "potential," "is likely," "expect" and similar expressions, as they relate to us, are intended to identify forward-looking statements. We undertake no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise, except as may be required by law.

Please follow us on:

LinkedIn: https://www.linkedin.com/company/solidion-tech

X: https://x.com/solidiontech?lang=en

SOURCE Solidion Technology, Inc.

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<p>New Designations Designed to Strengthen Leadership Structure to Advance Strategic Priorities and Execution DALLAS, Sept. 20, 2026 /PRNewswire/ -- Solidion Technology, Inc. (NASDAQ: STI) ("Solidion Technology" or "the Company"), an advanced battery technology solutions provider, today...</p>

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UD Info DB Series SSD Drives Achieve FIPS 140-3 Validation
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UD Info DB Series SSD Drives Achieve FIPS 140-3 Validation

Milestone completes a three-year security certification roadmap and advances secure storage for regulated industries and mission-critical applications

NEW TAIPEI CITY, Sept. 20, 2026 /PRNewswire/ -- UD info today announced that the cryptographic module integrated into its DB Series SSD Drives has achieved FIPS 140-3 validation through the National Institute of Standards and Technology (NIST) Cryptographic Module Validation Program (CMVP). NIST CMVP Certificate No. 5479, issued August 12, 2026, confirms validation at Overall Level 2.

The milestone provides independent assurance that the DB Series cryptographic module meets recognized security requirements. It also helps customers address security, compliance, and procurement requirements across government, critical infrastructure, and other mission-critical applications.

"FIPS 140-3 validation reflects our commitment to security backed by independent validation," said Gibson Chen, General Manager of UD info. "It strengthens our ability to help customers meet compliance requirements while delivering the performance, reliability, and long-term availability required for mission-critical applications."

FIPS 140-3 is the current U.S. federal security standard for cryptographic modules. This achievement completes UD info's three-year security roadmap, following FIPS 140-2 validation for the DA Series in 2024 and Common Criteria certification in 2025. Together, these milestones demonstrate UD info's investment in independently validated security and strengthen its position as a trusted secure-storage partner for regulated and mission-critical applications worldwide.

Designed for diverse system architectures and deployment environments, the DB Series is available in five certified configurations, combining hardware-based AES-XTS-256 encryption with NVMe PCIe performance and support for the TCG Opal Security Subsystem Class (SSC) protocol.

Full product specifications and datasheets are available for download at https://www.udinfo-tech.com/products/ruggedapplications.

UD info will continue to invest in certification, encryption, and firmware development to expand its secure storage portfolio. By combining validated security with strong firmware expertise and long-term supply commitments, UD info helps customers reduce integration risk and build dependable platforms for security-sensitive applications.

About UD info

UD info is a Taiwan-based manufacturer of industrial-grade storage solutions, including SSDs, SD and microSD cards, eMMC, USB flash drives, and DRAM modules. Backed by strong firmware engineering capabilities and long-term supply commitments, UD info serves customers worldwide across industrial automation, transportation, medical, energy, aerospace, rugged computing, and embedded systems. To learn more, visit www.udinfo.com.tw.

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[email protected] 

SOURCE UD info

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<p>Milestone completes a three-year security certification roadmap and advances secure storage for regulated industries and mission-critical applications NEW TAIPEI CITY, Sept. 20, 2026 /PRNewswire/ -- UD info today announced that the cryptographic module integrated into its DB Series SSD...</p>

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MetaOptics Secures up to US$10 Million Investment Facility from White Lion Capital, Its First U.S. Institutional Investor, to Onshore Metalens Technology into the U.S.
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MetaOptics Secures up to US$10 Million Investment Facility from White Lion Capital, Its First U.S. Institutional Investor, to Onshore Metalens Technology into the U.S.

SINGAPORE, Sept. 20, 2026 /PRNewswire/ -- MetaOptics Ltd (Catalist: 9MT) ("MetaOptics" or the "Company", and together with its subsidiaries, the "Group"), a leading-edge semiconductor optics company pioneering metalens technology, today announced that it has secured an investment facility of up to US$10 million from White Lion Capital LLC ("White Lion"), pursuant to a warrant deed entered into with White Lion, under which the Company may, upon exercise of the warrants by the holder at its discretion, raise up to US$10 million through the issuance of up to 40,000,000 new ordinary shares of the Company. White Lion, based in Los Angeles, California, is the first institutional investor in the United States ("U.S.") to participate in and invest in MetaOptics' growth story, a strong validation of MetaOptics' technology, solutions and commercialisation roadmap.

The investment comes one year after MetaOptics' listing on the Catalist board of the Singapore Exchange. It follows a period of strong commercial momentum, with design and evaluation requests from world-class customers and sampling units shipped. White Lion's participation extends the Company's investor base beyond Asia into the U.S., its largest end market.

The proceeds of up to US$10 million, upon exercise of the warrants, will accelerate MetaOptics' expansion in the U.S.. White Lion's investment will not just support ongoing projects with U.S. customers across consumer devices, co-packaged optics ("CPO") and optical interconnects, but more importantly, fund the establishment of the Group's maiden front-end semiconductor fabrication line with 12-inch DUV immersion photolithography equipment in the U.S., for the mass production of metalenses and module. The establishment of the Group's maiden front-end semiconductor fabrication line will not only onshore key metalens design, manufacturing and testing into the U.S., bringing such capabilities closer to U.S. customers, but also provide a shorter and clearer roadmap to securing purchase orders for the mass production of metalenses and modules.

The U.S. is a key market for metalens adoption, driven by consumer electronics, AR/VR wearables, automotive sensing and the multi-billion dollar CPO industry serving AI data centres. MetaOptics is currently working with several U.S. foundries to integrate its metalenses into their CPO designs. The smallest CPO metalens designed by MetaOptics measures 0.1 mm. The design can be scaled to a 12-inch semiconductor photolithography process on glass substrates, which is key to mass production.

"Securing our first U.S. institutional investor is an important step for MetaOptics," said Mr Thng Chong Kim, Executive Chairman of MetaOptics. "Many of our most important customers are in the U.S., from consumer device brands to the companies building CPO and optical interconnects for AI data centres. This funding allows us to move faster on their projects and to onshore key metalens technology into the U.S.."

"MetaOptics is one of the few companies in the world that can design, mass-produce and test glass-based metalenses at scale," said Gabriel Gumbiner, Senior Associate of White Lion. "We are particularly pleased that our first investment in an SGX-listed company is with an organization of MetaOptics' caliber. The company has a strong management team with a clear vision for its growth, and we are proud to support MetaOptics as it expands its presence in the U.S. market."

This press release is to be read in conjunction with MetaOptics' announcement on White Lion's investment facility of up to US$10 million, pursuant to a warrant deed entered into with White Lion, released via SGXNet on 21 September 2026. The Company will make further announcement(s) as and when appropriate.

About MetaOptics Ltd

MetaOptics Ltd (Catalist: 9MT) is a vertically integrated designer and manufacturer of metalens-based optical components and products, headquartered in Singapore. Founded in 2021, the Company uses semiconductor processes to pioneer glass-based colour metalenses and produce them at scale on both 4-inch and 12-inch platforms. Its portfolio spans metalenses, metalens camera modules, metalens manufacturing equipment and metalens IoT products, which customers integrate into applications including smartphones, contactless 3D biometrics, AR/VR devices, pico projectors, LiDAR and automotive sensing. MetaOptics aims to deliver high-performance optics with the reliability and scalability demanded by today's most innovative technology brands. Find out more at www.metaoptics.sg.

About White Lion Capital

White Lion Capital LLC is a US-based private investment firm headquartered in Los Angeles, California. The firm provides growth capital to public companies seeking to become leaders in emerging technology sectors.

Forward-Looking Statements

This press release may contain forward-looking statements that involve known and unknown risks, uncertainties and other factors, many of which are beyond the Company's control. A number of factors could cause actual results to differ materially from those contained in any forward-looking statement, including but not limited to the Company's growth strategies, its future business development, results of operations and financial condition, its research and development efforts, its ability to attract and retain customers, and its ability to establish and maintain relationships with suppliers and business partners; and assumptions underlying or related to any of the foregoing. All information provided in this press release is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.

Singapore (Headquarters)

MetaOptics Technologies Pte Ltd, 81 Ayer Rajah Crescent, #01-45, Singapore 139967

United States

MetaOptics Inc. (USA), 1 Ferry Building, Suite 201, San Francisco, CA 94111

SOURCE MetaOptics Ltd

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<p>SINGAPORE, Sept. 20, 2026 /PRNewswire/ -- MetaOptics Ltd (Catalist: 9MT) ("MetaOptics" or the "Company", and together with its subsidiaries, the "Group"), a leading-edge semiconductor optics company pioneering metalens technology, today announced that it has secured an investment facility...</p>

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Telix and ITM Join Forces to Create a Radiopharmaceutical Powerhouse
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- Transformational merger reinforces Telix's long-term growth strategy as a vertically integrated radiopharmaceutical company with enhanced capabilities across development, isotope production and global manufacturing, underpinned by commercial excellence and the industry's most extensive therapeutic pipeline.

- ITM is the world's leading supplier of therapeutic radioisotopes, with broad capabilities spanning lutetium-177 (177Lu), actinium-225 (225Ac) and terbium-161 (161Tb) production.

- ITM is the only producer of globally scaled commercial-grade 177Lu and serves as a key supplier for both commercially available and future therapeutic radiopharmaceuticals.

- ITM's commercial-scale and profitable isotope production business significantly contributes to cash generation while deepening Telix's supply chain for isotopes required for its therapeutics pipeline.

- ITM's complementary pipeline includes ITM-11 (177Lu-edotreotide), a novel therapeutic candidate for the treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), which has successfully completed Phase 3 development, potentially accelerating Telix's entry into a validated commercial market for targeted radionuclide therapy (TRT).

- Upfront consideration of US$1.65 billion on a cash-free/debt-free basis. After adjustments, ITM Shareholders are expected to be paid approximately US$1.25 billion in Telix Shares at US$11.84[1] per share, released as Nasdaq ADRs after the respective escrow periods.

- Additional contingent consideration of up to US$700 million upon achievement of future regulatory approvals and commercial sales milestones for ITM-11.

- The transaction is subject to Telix Shareholder approval and other customary closing conditions.

MELBOURNE, Australia, INDIANAPOLIS and MUNICH, Sept. 21, 2026 /PRNewswire/ -- Telix Pharmaceuticals Limited (ASX: TLX, NASDAQ: TLX, "Telix") today announces it has signed a strategic agreement to lead a merger with ITM Isotope Technologies Munich SE ("ITM"), a global leader in radioisotope production and radiopharmaceutical development.

The merger will further strengthen Telix's leadership as a vertically integrated radiopharmaceutical company with the capabilities required to develop, manufacture and deliver innovative treatments to patients globally. The combined organization will be uniquely positioned as a radiopharmaceutical industry leader, differentiated by a world-class scaled isotope manufacturing business with a validated global distribution network, a market-leading commercial precision medicine platform and the industry's most extensive therapeutic radiopharmaceutical pipeline.

Founded in 2004, ITM is a private company with a leading commercial scale radioisotope manufacturing and global distribution network spanning over 65 countries. ITM is a key supplier of 177Lu and – with a compound annual growth rate (CAGR) of 40% from 2021 to 2025 – delivered annual revenue of US$273 million in 2025[2]. This commercial momentum is underpinned by increasing global demand for TRT and radioisotopes for commercially approved products and assets under clinical development. The global nuclear medicine market is forecast to reach US$41 billion by 2034[3].

ITM's late-stage novel pipeline is complementary to Telix and includes ITM-11 (177Lu-edotreotide), a differentiated somatostatin receptor (SSTR)-targeted treatment for GEP-NETs. ITM-11 has completed a successful Phase 3 trial (COMPETE, NCT03049189)[4] and fully enrolled a second indication expansion Phase 3 study (COMPOSE, NCT04919226) with an interim analysis expected in H1 2027. If approved, ITM-11 has the potential to accelerate Telix's entry into the commercial therapeutic market and expand its presence in neuroendocrine tumors, a commercially validated and clinically significant market for TRT.

The combined organization is expected to generate unaudited pro forma 2026 revenue and income exceeding US$1.3 billion[5], based on management estimates. ITM's radioisotope manufacturing business is profitable and generates cash flow. Continued growth from manufacturing, cost savings and further targeted synergies and pipeline optimization are expected to support a positive EBITDA[6] contribution in 2027[7] and onward. If approved by health regulators, the launch of ITM-11 is expected to drive further upside, with the potential to generate additional high-margin therapeutic revenue in the near term.

Telix Managing Director and Group CEO, Dr. Christian Behrenbruch, said, "This merger positions Telix at the forefront of the consolidation that is occurring as the industry matures. ITM is the leader in radioisotope production, with deep scientific expertise and a track record of value-adding innovation. We have enjoyed a close working relationship with ITM for many years and there is strong management alignment for the rationale behind this transaction. By combining our complementary strengths, we will create a company with commercial scale, world-leading supply and the most exciting theranostic drug portfolio in the sector. Importantly, this combination further expands our late-stage therapeutic pipeline with two completed Phase 3 trials and deepens radioisotope security, while bringing together the mission-critical capabilities needed to deliver radiopharmaceutical treatments to patients around the world."

ITM Chief Executive Officer, Dr. Andrew Cavey, added, "Joining two radiopharmaceutical pioneers creates a company with unmatched breadth and depth across the value chain, supported by deep expertise and talent. Our management teams have a track record of working together and a nuanced understanding of our respective commercial strengths and customer relationships. Together, we believe Telix and ITM will be uniquely positioned to capitalize on rapidly growing global demand for radiopharmaceuticals to the benefit of both shareholders and patients."

Deal Terms

Under the terms of the agreement and subject to Shareholder approval, Telix will acquire 100% of the shares in ITM for US$1.65 billion upfront on a cash-free/debt-free basis expected as follows:

- US$1.25 billion will be paid to the sellers in the form of 105.8 million Telix shares (priced at the 30-day trailing VWAP as of signing of US$11.84[1]) and released to the sellers as Nasdaq-listed ADRs at the end of their respective escrow periods;

- US$302 million of net debt will be assumed by Telix at closing; and

- US$96 million of management equity rollover and transaction expenses payable by the sellers[8]; and in each case subject to closing adjustments.

Additional contingent consideration of up to US$700 million will become payable upon the achievement of specified regulatory approvals and sales milestones for ITM-11 as set out below:

- Up to US$250 million upon U.S. Food and Drug Administration (FDA) approval of ITM-11 across three different indications:

- US$100 million upon FDA approval for expected first indication in G1-G2 GEP-NETs no later than December 31, 2027;

- US$100 million upon FDA approval for G2-G3 GEP-NETs indication no later than December 31, 2030; and

- US$50 million upon FDA approval for Lung NETs indication no later than December 31, 2031; and

- Up to US$450 million based on ITM-11 net global sales in FY 2030 in excess of US$150 million.

All milestone consideration will be payable in cash or Shares[9] at Telix's election[10]. Consideration paid to ITM Shareholders at closing is subject to financial adjustments at closing, indemnity holdbacks, and escrow (lockup) restrictions on the Shares issued at closing of up to 15 months which may be waived in limited part to allow the sellers to pay their tax and transaction expense liabilities.

Upon completion of the transaction, Telix Shareholders will own approximately 76.3% and ITM Shareholders will own approximately 23.7% of Telix shares on issue. The transaction has been approved by Telix's Board of Directors and, as of signing, Shareholders holding over 90%[11] of ITM's Shares. The transaction is expected to close by the end of FY 2026 subject to Telix Shareholder approval as required under the ASX Listing Rules, regulatory approvals, and other customary closing conditions.

Refer to the Investor Presentation lodged today with the ASX for further information on the transaction.

A Notice of Meeting will be sent to Telix Shareholders for an extraordinary general meeting expected to be held in November 2026.

Advisors

Morgan Stanley Australia Limited acted as exclusive financial advisor to Telix. Sidley Austin LLP and Herbert Smith Freehills Kramer LLP acted as legal counsel to Telix. Centerview Partners acted as exclusive financial advisor to ITM. Latham & Watkins LLP acted as legal counsel to ITM.

About ITM Isotope Technologies Munich SE

ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiopharmaceutical therapeutics and diagnostics for hard-to-treat tumors. The company aims to meet the needs of cancer patients, clinicians, and partners through excellence in development, production, and global supply of medical radioisotopes. With improved patient benefit as the driving principle for all it does, ITM advances a broad precision oncology pipeline, including multiple Phase 3 studies, combining the company's high-quality radioisotopes with a range of targeting molecules. By leveraging two decades of pioneering radiopharma expertise, its respected industry position and its established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcomes and quality of life.

ITM is headquartered in Munich, Germany with two GMP manufacturing sites and a global distribution network spanning 65 countries. Through its agreement with Isogen, ITM has 15-year exclusive access to Bruce Power's nuclear reactors in Canada for the irradiation services required to manufacture 177Lu. For further information, visit: www.itm-radiopharma.

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Abbisko Therapeutics Announces Positive Preliminary Phase 2 Results with Lavengratinib (ABSK061) for the Treatment of Achondroplasia
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SHANGHAI, Sept. 20, 2026 /PRNewswire/ -- 21 September 2026 (Beijing time), Abbisko Therapeutics Co., Ltd. ("Abbisko Therapeutics" hereafter, HKEX code: 02256.HK) today announced positive preliminary efficacy results from the Phase II clinical study of lavengratinib (ABSK061), a selective orally available small-molecule FGFR2/3 inhibitor, in children with achondroplasia (ACH). In the first and lowest dose cohort of 0.064mg/kg QD, children aged 6 years and older with ACH who received lavengratinib for 27 weeks achieved a mean increase of +2.4 cm/year in annualized height velocity (AHV) from baseline, with a 100% responder rate*. Lavengratinib was well-tolerated with no observed FGFR1 or FGFR2-associated adverse events (AEs).

ABSK061-202 is a Phase II, multicenter, open-label, dose-escalation study designed to evaluate the safety and efficacy of lavengratinib (once daily, orally administered) in children aged 3 to 12 years with ACH. All participants will receive lavengratinib for a planned treatment duration of 78 weeks. To date, all seven participants aged 6 to 12 years in cohort 1 have completed six months of treatment and achieved encouraging preliminary results:

- Preliminary data demonstrate positive signals for growth promotion. At Week 27, the seven participants in the first and lowest dose cohort (0.064 mg/kg, once daily) achieved a mean improvement of +2.4 cm/year in AHV from baseline, with a responder rate* of 100%. Participants enrolled in higher dose cohorts are currently ongoing treatment.

- Overall safety and tolerability were favorable. To date, no serious adverse events (SAEs) or treatment discontinuations due to AEs have been reported. No specific safety risks associated with FGFR pathway inhibition have been observed to date, including FGFR1 or FGFR2-associated AEs such as hyperphosphatemia and corneal toxicity.

- Lavengratinib leverages Abbisko's unique oral mini-tablet formulation. Abbisko's unique mini-tablet formulation, with each tablet being less than 3mm in diameter as compared to conventional tablets ~8-10mm in diameter, allows for easy administration with children. Such mini-tablets can be conveniently administered with food and drink.

The ABSK061-202 study has successfully completed the preliminary safety evaluation of the first three dose cohorts, with no safety concerns identified to date. Six-month efficacy and safety results are expected by the end of 2026, providing further evidence to support the evaluation of the clinical potential of lavengratinib in children with ACH.

*Responder is defined as a participant achieving an ≥25% improvement in AHV from baseline.

About Lavengratinib (ABSK061)

Lavengratinib is a novel, orally bioavailable, highly potent and selective small molecule inhibitor of FGFR2 and FGFR3 independently discovered and wholly-owned by Abbisko Therapeutics. It is the first FGFR2/3 inhibitor to enter clinical trials globally. First-generation pan-FGFR inhibitors demonstrated clinical efficacy in multiple tumors carrying FGFR2/3 variants and have steadily gained regulatory approval globally. However, the therapeutic window of pan-FGFRs and their clinical efficacy have been limited by side effects associated with FGFR1 inhibition. By reducing FGFR1 activity while maintaining potency against FGFR2 and FGFR3, lavengratinib is expected to achieve a wider therapeutic window with improved clinical efficacy as a new-generation of FGFR inhibitors. lavengratinib for the treatment of achondroplasia has received both Rare Pediatric Disease Designation (RPDD) and Orphan Drug Designation (ODD) from the U.S. Food and Drug Administration (FDA), and its Phase II clinical trial is currently ongoing.

SOURCE Abbisko

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<p>SHANGHAI, Sept. 20, 2026 /PRNewswire/ -- 21 September 2026 (Beijing time), Abbisko Therapeutics Co., Ltd. ("Abbisko Therapeutics" hereafter, HKEX code: 02256.HK) today announced positive preliminary efficacy results from the Phase II clinical study of lavengratinib (ABSK061), a selective...</p>

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