Hippocratic AI Unveils Polaris 6 Ultra, the First Healthcare Model With Bedside Intuition, Built on Real-Life Experience, With Lower Pricing
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Larger model brings new advancements to healthcare AI: Reads the patient and plans its next sentence while speaking, more realistic voice with clinical hearing. Ran 7.4-trillion-parameter safety constellation 1.3 times faster than its predecessor

MENLO PARK, Calif., Nov. 2, 2026 /PRNewswire/ -- Hippocratic AI today announced Polaris 6 Ultra, a new generation of its healthcare language model that delivers six upgrades to how an AI care agent listens, thinks, and speaks. Polaris 6 Ultra is the first healthcare model with what the company calls bedside intuition: the ability to read a patient's emotional state, think mid-speech and decide what to say next in the same breath, without a pause the patient can hear.

"In healthcare, you don't get credit for reminding a patient. You get credit for the action they take," said Munjal Shah, Co-Founder and CEO of Hippocratic AI. "Polaris 6.0 was built from more than 323 million patient conversations, making it the only truly experienced frontier model for healthcare able to operate safely and autonomously to drive patient outcomes. That experience shows. Polaris 6.0 handles the healthcare edge cases of real life, it now has more human-like common sense and pacing, and it delivers the kind of empathy that persuades patients."

General-purpose models aren't built to address healthcare edge cases, or handle the realities of patient care. Traditional LLMs expect clean audio, reason before they speak, know only what is written down, read every line in one tone, and get slower as they get smarter. That doesn't work for healthcare.

"Everyone building voice AI for healthcare trades off model size for latency: speech-to-speech models are fast and shallow, reasoning models are capable and slow," said Subhabrata Mukherjee, Co-Founder and Chief Science Officer. "We refused that choice. We took the largest model that could be made safe and rebuilt the entire stack for voice, from the GPU numerics to the breath in the synthesized voice. Then, with full-parameter reinforcement learning at frontier scale, we gave Polaris 6 not just safety but common sense, intuition, and the warmth and realism of an experienced clinician."

With increased EHR integration and new flexible pricing, Polaris can now meet the needs of any healthcare client. Polaris 6.0 ships as Ultra (full constellation, all 31 supervisors, for clinical patient-facing conversations), Pro (sub-clinical workloads), Flash (high volume, subclinical), and Nano [administrative use cases], so customers can match coverage and speed to their specific needs.

Polaris 6 Ultra closes all six gaps at once:

- AI Intuition (v1) â more persuasive. The model generates an unspoken planning span before every sentence while the previous sentence's audio is still playing, reading the patient's mood and resistance and deciding what to bring up now and what to save. Time to first sentence stays at 278 milliseconds for the LLM. Every plan is logged against the sentence it produced and shown in the Safety Portal beside the transcript, so a clinician can audit, sentence by sentence, which risk the model noticed and which it deferred.

- Care Voice (v3) â more empathetic. The third generation of the Polaris voice is the first directed by the model rather than narrated. Breath, sighs, laughter, pauses and tempo are emitted as tokens from the plan, so pacing adapts to the patient's state and tone shifts before the words do. An in-house text-to-speech model pronounces 90% of 629 evaluated drug names correctly, versus 75% for the leading commercial TTS.

- Common Sense 2.0 â more common sense. Full-parameter reinforcement learning on the 671B primary model, end to end for the first time in a Polaris release, moved Hippocratic AI's internal healthcare-intelligence benchmark 18 points over its own base and 11 points past the best frontier model, with the largest gains in escalation and transfer, the first thirty seconds of a call, language switching, and call endings.

- Clinical ASR (CASR v3) â more inclusive. An in-house audio-LLM conditioned on the conversation and the chart hears patients who mumble, are recovering from a stroke, or are calling from a landline with the television on. On 2,778 clinician-reviewed production calls, misheard medications or symptoms fell from 1.19 to 0.20 per 100 calls, misheard numbers, names and emails fell from 0.57 to 0.00, and words invented on noise-only audio fell from 24% to 0.6%. Television speech attributed to the patient fell from 64.8% to under 3%.

- 7.4 trillion parameters â smarter makes it safer. The 671B primary model now runs inside a constellation of 30 specialist supervisors and 142 production monitors, up from 5.0 trillion parameters in Polaris 5, checking every turn in parallel across escalation and crisis response, medications, identity and consent, scheduling, privacy, and conversational quality.

- 1.3Ã faster â unlocks real-time thinking. Blackwell-native 4-bit numerics, routing-aware mixture-of-experts scheduling, first-token speculative decoding, and a serving engine Hippocratic AI owns deliver a 1.3Ã end-to-end speedup over Polaris 5 as patients experienced it, earned while the constellation grew and the model began reasoning mid-sentence. On byte-identical prompts on a 671B parameter LLM, the stack reaches the first sentence in 0.28 seconds versus 0.71 to 0.94 seconds for the four fastest commercial providers.

Across generations, the clinician-measured safety of the Polaris constellation has held at its ceiling since Polaris 4; with the latest constellation, the minor-harm rate in clinician output testing retains 0.00%. What has moved is the part patients feel: how natural, how perceptive, and how fast the agent is. Polaris 6 Ultra ships under the same criterion as every Polaris release: clinically tested, validated by licensed clinicians, and governed under human oversight before it reaches a patient.

Hippocratic AI builds and deploys safe conversational voice AI agents that address healthcare's biggest problems with a mission to transform patient outcomes through healthcare abundance. Built on Polaris, the company's patented, safety tested constellation model, Hippocratic AI's agents have completed more than 250 million patient voice interactions across more than 300 live clinical use cases, with zero safety issues in production. Hippocratic AI has received a total of $444 million in funding and is backed by leading investors, including Andreessen Horowitz, General Catalyst, Kleiner Perkins, Avenir, NVIDIA's NVentures, Premji Invest, SV Angel, Google's CapitalG, and numerous health systems. Hippocratic AI stands behind its safety promise â its contracts allow the company to take responsibility for its agents. Founded on the principle "do no harm," the company's agents do not diagnose or prescribe. Learn more at hippocraticai.com.

SOURCE Hippocratic AI

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<p>Larger model brings new advancements to healthcare AI: Reads the patient and plans its next sentence while speaking, more realistic voice with clinical hearing. Ran 7.4-trillion-parameter safety constellation 1.3 times faster than its predecessor MENLO PARK, Calif., Nov. 2, 2026...</p>

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Global Industrial Automation Market to Hit US$ 410.3 Billion by 2031, Registering 9% CAGR: Wissen Research
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SHERIDAN, Wyo., Nov. 2, 2026 /PRNewswire/ -- The global industrial automation market is valued at USD 266.7 billion in 2026 and is projected to reach USD 410.3 billion by 2031, growing at a CAGR of 9% over the forecast period (2026â2031), according to a new study by Wissen Research.

The clearest evidence is on the factory floor. The International Federation of Robotics (IFR) reports that factories installed a record 603,000 industrial robots in 2025, up 11% from the year before, and that the global operational stock reached 5.079 million units. IFR forecasts installations to rise another 9% in 2026, to approximately 655,000 units.

Behind the robots is a broader shift. The market is moving from hardware-oriented, isolated machine control toward connected, software-based production that combines control hardware, robotics, industrial software, and real-time analytics. Demand is driven by labor shortages, rising quality standards, and the need to control complex processes in automotive, electronics, food, and pharmaceutical manufacturing.

Get a Free Sample of This Report to Explore Key Findings and Data: https://www.wissenresearch.com/request-a-sample/?report=industrial-automation-market

Industrial AI Has Moved From Pilot Projects Into Live Operations

Cisco's 2026 State of Industrial AI study found that 61% of surveyed organizations were using AI in live industrial operations, and 83% planned to increase their AI spending. The use cases already delivering results are practical ones: predictive maintenance, process automation, automated quality inspection, logistics, and energy forecasting. Machine vision systems powered by AI can spot defects and abnormal conditions, and AI can adjust process parameters as production conditions change.

Getting there is harder than buying software. AI has to be integrated with industrial control systems, edge computing, and data platforms, which depends on good machine data, working IT and operational technology (OT) connections, and the state of legacy systems. In the same Cisco study, 97% of respondents expected AI workloads to affect their industrial network requirements, 51% anticipated higher connectivity and reliability requirements, and 43% reported limited or no collaboration between IT and OT teams. The report sees opportunities in industrial networking, edge devices, and real-time data infrastructure alongside conventional automation hardware, and in digital twins, which let companies test production changes virtually before implementing them.

Robots Move Beyond the Car Factory

For years, industrial robotics meant automotive welding and material handling. The IFR data show a broader base. In 2025, robot installations in metal and machinery grew 22%, while automotive and electronics installations each rose 10%. Collaborative robots (cobots) accounted for 66,000 new installations, about 11% of the total, and autonomous mobile robots are taking on internal transport. The growth is concentrated geographically: China installed about 354,000 robots in 2025, roughly 59% of the global total and 20% more than the year before, while India installed nearly 10,500, up 15%, with annual installations growing an average of 27% between 2020 and 2025.

The competitive map is shifting with it. Chinese robot manufacturers supplied 55% of the industrial robots installed in China in 2025, up from approximately 28% a decade earlier, intensifying competition for established international vendors.

Get a Custom Briefing on This Market for Your Business

Wissen Research's analysts are available to walk through findings specific to your market, region, or competitive set.

Need Insights Specific to Your Business? Request a Customized Version of This Report: https://www.wissenresearch.com/request-customization/?report=industrial-automation-market

What's Fueling Growth in the Industrial Automation Market

- Semiconductor manufacturing capacity: New wafer plants need tight control of temperature, pressure, gas flow, and contamination, which raises demand for automation systems, sensors, robots, and integrated control systems.

- Electrified vehicle production: Battery manufacturing, motor assembly, and battery pack integration need automated material handling, robotic welding, vision-based inspection, and traceability to keep high-volume production consistent.

- Pharmaceutical traceability and process regulation: Complex biopharma production and regulatory traceability requirements call for automated inspection, batch control systems, paperless technology, and accurate dosing tools.

- Food inspection and packaging: High-speed lines rely on machine vision, automated weighing, fill-level verification, and reject systems to cut product loss and ensure correct packaging.

- Brownfield modernization: Companies are replacing outdated programmable logic controllers (PLCs), old drives, and unintegrated automation with connected platforms that improve equipment visibility and enable remote diagnostics without a complete plant renovation.

- Energy optimization: Chemical, oil and gas, and metals producers are adopting advanced process control, variable frequency drives, and real-time monitoring to stabilize processes and reduce energy use per unit of output.

Challenges Facing the Industrial Automation Market

The upfront cost is the first barrier. Replacing an old control system often means interrupting production, reconfiguring hardware, upgrading software, and validating the result, and companies with several production sites can struggle with incompatible communication standards and production methods. In pharmaceutical and food manufacturing, automated processes may need significant validation before they go live, and smaller businesses can find it hard to finance automation projects.

Connectivity brings industrial cybersecurity risk. Honeywell's 2026 OT Cybersecurity Benchmark Report found that only 21% of surveyed organizations had a complete inventory of their operational technology assets, even though 88% described their cybersecurity programs as mature. Respondents reported an average of 16.2 hours of downtime from their most significant incidents, with losses reaching up to USD 500,000 per hour. The 2025 SANS ICS/OT Security Survey found that only 49% of surveyed organizations had detection capabilities designed specifically for industrial control systems, and just 26% of that group considered them highly effective. Recovery can be slow even when detection is quick: nearly half of surveyed incidents were detected within 24 hours, but almost one in five took more than a month to remediate fully.

Recent Strategic Developments in the Industrial Automation Market

In September 2026, Emerson Electric Co. of the United States announced plans for a 3,500-square-meter automation solutions service center in Qatar's Umm Alhoul Free Zone, featuring the region's first certified in-country flow calibration laboratory. The facility will provide measurement instrumentation, control system integration, spare parts, and training services to improve operational efficiency and reduce customer downtime across the Middle East and Africa.

In July 2026, City Electric Supply of the United States partnered with Siemens Digital Industries of Germany to expand industrial automation and control solutions through its Industrial Automation Solutions division. The partnership strengthened its capabilities in PLC systems, control panels, drives, SCADA, application engineering, and troubleshooting for smart manufacturing and automation customers across North America.

In July 2026, ABB Ltd. of Switzerland agreed to acquire Rotork plc of the United Kingdom through a recommended all-cash offer valued at approximately USD 5.5 billion, aiming to expand its portfolio in intelligent flow control, electric actuators, and instrumentation and to strengthen its field-device and industrial process automation capabilities.

In July 2026, American Industrial Partners completed its acquisition of Honeywell International Inc.'s Intelligrated and Transnorm businesses, combining them with Trew to create a warehouse automation provider. The combined organization offers conveyor systems, robotics, sortation, automated storage and retrieval systems, software, and lifecycle services, and generated over USD 1 billion in 2025 revenue.

The four deals cover service networks, distribution, field devices, and warehouse automation, a reminder that portfolios are being reshaped from several angles at once.

Key Insights from Industrial Automation Market Analysis

- Industrial robotics held a strong position in 2025, supported by rising automation across manufacturing, demand for production precision, and flexible robotic systems. FANUC, Yaskawa, ABB, and KUKA compete in robotics, motion control, and integrated manufacturing automation.

- Automotive and transportation remained a major application in 2025. Automotive manufacturers installed 126,088 industrial robots worldwide in 2024, about 23.3% of the 542,000 installed that year, although electronics manufacturers installed slightly more (128,899), showing how closely the two industries compete for robotics demand. Electric vehicle production adds automated battery-cell handling, pack assembly, robotic joining, and testing to conventional assembly lines.

- Asia-Pacific held the leading regional position in 2025. Asia accounted for 74% of global industrial robot installations in 2024, compared with 16% in Europe and 9% in the Americas, and the United Nations Industrial Development Organization (UNIDO) reported that global manufacturing output in higher-technology industries grew 5.8% in 2025.

- The market is moderately consolidated. A few large multinationals compete alongside specialized technology providers.

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<p>SHERIDAN, Wyo., Nov. 2, 2026 /PRNewswire/ -- The global industrial automation market is valued at USD 266.7 billion in 2026 and is projected to reach USD 410.3 billion by 2031, growing at a CAGR of 9% over the forecast period (2026–2031), according to a new study by Wissen Research. The...</p>

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Abracon Expands Digital Customer Experience with New Website Accounts Designed for Engineers
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AUSTIN, Texas, Nov. 2, 2026 /PRNewswire/ -- Abracon, a leading global manufacturer of frequency control, timing, power, magnetics, RF, antenna, and connectivity solutions, today launched website accounts that give engineers and design teams a more personalized way to explore products and manage their interactions with the company, including the ability to request or purchase samples and download support files.

With a free Abracon account, engineers can:

- Request or purchase samples of eligible parts for evaluation

- Download support files, including 3D models, symbols, footprints, and simulation files

- View order history and status updates, including tracking information, for samples and purchases placed on abracon.com

Together, these features help engineers move more efficiently from initial component research to design validation.

"As customer expectations continue to evolve, Abracon remains committed to investing in digital tools that make it easier to engage with our products and services," said Kevin Lemon, Vice President of Global Product and Marketing at Abracon. "This new account functionality is another step toward a seamless experience at every stage of the design journey."

The accounts complement Abracon's established sales and distribution channels, which continue to play an important role in helping customers research, design, and purchase. They also build on the company's recent investments in website search, online product accessibility, and e-commerce.

Website accounts are the foundation for the enhanced digital experience Abracon will continue to build as the platform evolves. Create an account at www.abracon.com today to start using these features and to access new capabilities as they are added.

For more information about Abracon and its product portfolio, visit www.abracon.com.

About Abracon, LLC | Innovation For Tomorrow's Designs

Headquartered outside of Austin, Texas, Abracon is a trusted supplier of leading-edge and innovative electronic components including Frequency Control, Timing, Power, Magnetics, RF and Antenna solutions. Servicing world-class companies across data communication, transportation, industrial, medical, consumer, aerospace, and defense industries, Abracon accelerates customers' time-to-market by providing unmatched product solutions, technical expertise, and service excellence.

SOURCE Abracon, LLC

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<p>AUSTIN, Texas, Nov. 2, 2026 /PRNewswire/ -- Abracon, a leading global manufacturer of frequency control, timing, power, magnetics, RF, antenna, and connectivity solutions, today launched website accounts that give engineers and design teams a more personalized way to explore products and...</p>

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During Gateway Gulf 2026: Beyon Announces Expansion of Green Data Centre Portfolio to Three Centres as Solar Investment Accelerates
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During Gateway Gulf 2026: Beyon Announces Expansion of Green Data Centre Portfolio to Three Centres as Solar Investment Accelerates

- Latest phase will deliver 2.5 GWh of clean energy annually and reduce COâ emissions by more than 1,585 tonnes each year

MANAMA, Bahrain, Nov. 2, 2026 /PRNewswire/ -- Beyon has announced the expansion of its green data centre portfolio, with a third data centre set to become fully powered by renewable energy following the completion of Phase 5 of the Beyon Solar Park programme. Announced during Gateway Gulf 2026 in the presence of H.E. Shaikh Abdulla bin Khalifa Al Khalifa, Chairman of Beyon Group, the milestone represents the latest advancement in Beyon's long-term investment in sustainable infrastructure and renewable energy.

Developed in partnership with Almoayyed Solar, Phase 5 represents an investment of approximately BD544,500 and will extend across 14,000 square meters, incorporating 2,292 solar panels. The installation has a total capacity of 1.5 MWp. Once completed in the coming months, the installation is expected to generate approximately 2.5 GWh of clean energy annually and reduce carbon emissions by more than 1,585 tonnes of COâ each year.

The completion of Phase 5 will bring the number of Beyon green data centres powered by renewable energy to three, further strengthening the Group's sustainable digital infrastructure. As demand for data, cloud and digital services continues to grow, this expansion supports Beyon's ambition to develop resilient, high-performance infrastructure while progressively reducing the environmental impact associated with its operations.

The Solar programme has also continued to expand beyond Beyon's Data centres. During 2026, Beyon successfully completed Phase 4, extending renewable energy adoption to Total CX's Customer Contact Centre, making it the first green contact centre in Bahrain.

The latest development builds on the milestone announced at Gateway Gulf 2025, when Phase 3 of the Solar Park enabled Beyon's Tier III Certified Data Center in Hamala to operate entirely on renewable energy. The continued investment reflects a multi-year programme to increase the contribution of clean energy across Beyon's infrastructure and support customers pursuing their own sustainability and ESG objectives.

Beyon Group CEO Andrew Kvaalseth said, "Data centres are increasingly fundamental to the digital economy, and we believe their continued expansion should go hand in hand with a more sustainable approach to powering critical infrastructure. Reaching three green data centres represents an important milestone in that journey and reflects the scale and consistency of our investment in renewable energy. As we continue to grow our digital infrastructure, sustainability and resilience will remain integral to how we invest for the future."

Almoayyed International Group Chairman Mohammed Almoayyed said, "Our partnership with Beyon continues to demonstrate the potential of long-term collaboration to deliver renewable energy infrastructure at meaningful scale. The successive phases of the Solar Park programme reflect a clear and sustained commitment to clean energy, and we are pleased to support Beyon as it continues to expand the programme across its critical infrastructure."

Beyon and Almoayyed Solar's collaboration forms part of a long-term programme to expand the use of renewable energy across the group's infrastructure. The continued expansion reinforces Beyon's commitment to integrating renewable energy into its infrastructure and contributing to the Kingdom of Bahrain's sustainability and carbon-reduction ambitions.

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LinkedIn: https://www.linkedin.com/company/beyon-bh/posts/?feedView=all

ABOUT BEYON:

Beyon is a global technology group, dedicated to bringing technology closer to people and businesses with best-in-class connectivity and digital solutions. As a group, Beyon is focused on creating a prosperous digital growth portfolio through its subsidiary companies Batelco, Beyon Money, Beyon Cyber, Beyon Solutions, and Beyon Connect. Beyon also supports a successful group of international investments, subsidiaries and affiliates in several locations including Jordan, Saudi Arabia, Yemen, Egypt, the Maldives, The Channel Islands, Isle of Man, Diego Garcia, St. Helena, Ascension Island, and the Falkland Islands.

Beyon is a listed entity on the Bahrain Bourse, for more information visit www.beyon.com

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<p>- Latest phase will deliver 2.5 GWh of clean energy annually and reduce CO₂ emissions by more than 1,585 tonnes each year MANAMA, Bahrain, Nov. 2, 2026 /PRNewswire/ -- Beyon has announced the expansion of its green data centre portfolio, with a third data centre set to become fully...</p>

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Neurocrine Biosciences Reports Third-Quarter 2026 Financial Results
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Total Third-Quarter 2026 Revenue Grew 41% Year-Over-Year to $1.1 Billion

INGREZZA® (valbenazine) 2026 Net Sales Guidance Raised to $2.9 to $2.925 Billion

SAN DIEGO, Nov. 2, 2026 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced its financial results for the third quarter ended September 30, 2026.

"Our third quarter performance marks another important milestone in Neurocrine's evolution, with net product sales exceeding $1 billion for the first time, driven by strong underlying demand across our diversified portfolio of first-in-class medicines," said Kyle W. Gano, Ph.D., Chief Executive Officer of Neurocrine Biosciences. "This continued growth reinforces the strength of our strategy and expands our capacity to invest in innovation, advance our pipeline and build an enduring biopharmaceutical company. Looking ahead to 2027, we see meaningful opportunities for continued growth across INGREZZA, CRENESSITY® (crinecerfont) and VYKAT® (diazoxide choline) XR, alongside multiple important clinical milestones, including Phase 3 readouts for osavampator in major depressive disorder and direclidine in schizophrenia."

Total Revenue Highlights

- Total revenues for the third-quarter 2026 were $1.1 billion, compared with $795 million in the prior-year period representing 41% year-over-year growth.

- INGREZZA third-quarter 2026 net product sales were $801 million, representing 17% growth year-over-year. Results reflected double-digit volume growth, with record TRx and NRx supported by strong demand and high rates of persistency.

- INGREZZA full year 2026 guidance was increased from a range of $2.825 billion to $2.875 billion up to $2.9 billion to $2.925 billion.

- CRENESSITY third-quarter 2026 net product sales were $211 million, driven by steady new patient demand and high rates of persistency with approximately 80% reimbursement for dispensed prescriptions.

- VYKAT XR third-quarter 2026 net product sales were $107 million, driven by steady and consistent patient demand and persistency.

Recent Clinical and Corporate Developments

- Announced the initiation of a Phase 1 first-in-human clinical study evaluating the safety and tolerability of NBIP-'1968, an investigational GLP-1/GIP/glucagon receptor triple agonist being developed as a therapy for obesity. This follows the Q1 2026 initiation of a Phase 1 first-in-human clinical study of NBIP-'2118, a potential first-in-class CRF2 peptide agonist. Initial clinical data from both programs will inform the development of a novel co-formulated combination therapy, including the optimal ratio of the two agents. NBIP-'2118 will also be evaluated independently as a potential standalone therapy for obesity.

- Announced the initiation of a Phase 2 clinical study evaluating the efficacy, safety, tolerability and pharmacokinetics of NBI-'567, an investigational M1/M4 (M1-preferring) selective muscarinic agonist being developed as an adjunctive therapy for cognitive impairment in Alzheimer's disease.

- Announced publication of the KINECT-PRO⢠Phase 4 open-label study results demonstrating that treatment with once-daily INGREZZA capsules resulted in substantial and sustained improvements in patient-reported quality of life and functionality, alongside improvements in clinician-rated tardive dyskinesia (TD) movement severity. Improvements were observed regardless of underlying psychiatric diagnosis or baseline TD movement severity, including among participants with clinician-rated mild TD movements. The manuscript appears in CNS Spectrums.

- Presented research advancing the understanding of Prader-Willi syndrome and real-world experience with VYKAT XR at the Foundation for Prader-Willi Research Symposium & Family Conference.

- Announced that Eiry W. Roberts, M.D., who previously served as Neurocrine's Chief Medical Officer and most recently as a Strategic Advisor, has rejoined the Company's executive management team as Chief Medical Officer (CMO).

- Company to host R&D Day in New York on December 15, 2026.

Third-Quarter 2026 Financial Results

- Third-quarter 2026 GAAP net income and earnings per share were $207 million and $1.96, respectively, compared with $210 million and $2.04, respectively, for third-quarter 2025.

- Third-quarter 2026 Non-GAAP net income and earnings per share were $347 million and $3.29, respectively, compared with $222 million and $2.17, respectively, for third-quarter 2025.

- A reconciliation of GAAP to Non-GAAP financial results can be found in Table 3 at the end of this press release.

- Third-quarter 2026 GAAP and Non-GAAP net income compared with third-quarter 2025 were primarily driven by:

- Higher net product sales of $329 million.

- Third-quarter 2026 GAAP operating expenses included certain expenses associated with the acquisition of Soleno Therapeutics, Inc. (Soleno), which closed in May 2026, and are excluded from Non-GAAP operating expenses.

- Increased R&D expense in support of an expanded and advancing pre-clinical and clinical portfolio included investments in the osavampator Phase 3 program in major depressive disorder (MDD) and the muscarinic franchise, including the direclidine Phase 3 program as a potential treatment for adults with schizophrenia. Development milestone expense included in R&D was $10 million and $1 million, respectively, for the third quarter 2026 and 2025.

- Increased SG&A expense primarily reflected continued investment in our commercial organization, included the expansion of our INGREZZA and CRENESSITY sales teams in the first quarter of 2026 and for support of VYKAT XR following the acquisition of Soleno, which closed in May 2026.

- Third-quarter 2026 includes $52 million loss from changes in fair values of equity investments, compared with a gain of $31 million for third quarter 2025 (Non-GAAP adjustment)

- At September 30, 2026, the Company had cash, cash equivalents, and marketable securities totaling approximately $790 million.

Full Year 2026 Financial Guidance

- INGREZZA sales guidance reflects expected net product sales of INGREZZA in tardive dyskinesia and chorea associated with Huntington's disease.

- R&D guidance reflects the continued advancement of the Company's pre-clinical and clinical portfolio including the Phase 3 programs for osavampator in major depressive disorder and direclidine in schizophrenia, and includes approximately $33 million of expense for development milestones related to our in-licensed product candidates. Development milestones are included in R&D guidance once achieved or deemed probable to achieve.

- Non-GAAP guidance has been adjusted to exclude estimated non-cash stock-based compensation expense of approximately $115 million in R&D and $170 million in SG&A, including approximately $58 million related to the acceleration of vesting of equity awards for Soleno employees which vested in full upon the closing of the transaction, and acquisition, integration and divestiture-related expenses of approximately $95 million. Non-cash stock-based compensation expense for performance-based equity awards is included in guidance once the predefined performance-based criteria for vesting is achieved or deemed probable to achieve.

- IPR&D guidance represents completed collaboration and licensing arrangements.

- SG&A guidance reflects expense for ongoing commercial initiatives, including the recent expansion of our sales teams in Q1 2026, supporting INGREZZA growth and the launch of CRENESSITY and VYKAT XR.

- In connection with the acquisition of Soleno, the Company recorded approximately $2.2 billion of intellectual property related to VYKAT XR to the balance sheet, which will be amortized over an expected life of 16 years.

Conference Call and Webcast Today at 4:30 PM Eastern Time

Neurocrine Biosciences will hold a live conference call and webcast today at 4:30 p.m. Eastern Time (1:30 p.m. Pacific Time). Participants can access the live conference call by dialing 800-347-6865 (US) or 203-518-9757 (International) using the conference ID: NBIX. The webcast and accompanying slides can also be accessed at approximately 4:30 p.m. Eastern Time on Neurocrine Biosciences' website under Investors at www.neurocrine.com. A replay of the webcast will be available on the website approximately one hour after the conclusion of the event and will be archived for approximately one month.

About Neurocrine Biosciences

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)

NEUROCRINE, the NEUROCRINE BIOSCIENCES Logo, YOU DESERVE BRAVE SCIENCE, INGREZZA, and CRENESSITY are registered trademarks of Neurocrine Biosciences, Inc. VYKAT is a registered trademark of Soleno Therapeutics, Inc.

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<p>Total Third-Quarter 2026 Revenue Grew 41% Year-Over-Year to $1.1 Billion INGREZZA® (valbenazine) 2026 Net Sales Guidance Raised to $2.9 to $2.925 Billion SAN DIEGO, Nov. 2, 2026 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced its financial results for the third...</p>

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Spire Missouri rate case filing supports continued investments in safety and reliability
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ST. LOUIS, Nov. 2, 2026 /PRNewswire/ -- Today, Spire Missouri filed a rate case with the Missouri Public Service Commission (PSC) to support continued investments in its natural gas system that enhance safety, reliability and service for customers.

"Our focus is on safely and reliably delivering affordable natural gas service to more than 1.2 million Missouri customers," said Steve Mills, Spire Missouri president. "Since our last rate case, we've continued to modernize and upgrade our system, benefiting customers with enhanced reliability and fueling economic growth and job creation. We are fortunate to be both a trusted energy provider and a trusted community partner across Missouri."

If the request is approved as filed, assuming current natural gas market conditions, the average residential bill would increase approximately $10 per month, or 11%, for Spire customers in western Missouri. In eastern Missouri, the average bill for residential customers would increase approximately $13 per month, or 15%. New rates would go into effect next fall as the PSC typically completes its review of a rate case within approximately eleven months of filing.

Investments to better serve customers

Since Spire Missouri's last rate case, the utility has continued to make investments in its delivery system and technology to benefit customers. These include:

- Spire has invested nearly $808 million to maintain and modernize its Missouri natural gas system, enhancing safety and reliability of its distribution system while reducing emissions.

- New infrastructure reduces ongoing maintenance costs and enhances reliability and service for the future. It also ensures that Missouri has the energy infrastructure needed to support communities, economic growth and job creation.

- During FY26, Spire helped support 24 publicly announced economic development projects in Missouri, representing an investment of nearly $537 million in the state economy and resulting in the creation of more than 1,400 jobs. Access to natural gas played a key role in securing many of these projects.

Assistance is available for customers

Spire remains committed to keeping bills as low as possible for customers. According to data from the American Gas Association, natural gas continues to be more cost-effective than other energy sources as customers who use natural gas to heat homes, dry clothes and heat water save more than $1,000 annually when compared to those who use electricity. In fact, in Missouri, electricity is more than two times more expensive than natural gas.

For some customers who are vulnerable, any cost increase can carry disproportionate impact. That's why Spire is committed to finding effective ways to help. During fiscal 2026, Spire connected Missouri customers with nearly $14 million in federal, state and Spire energy assistance funding to help pay their natural gas bills, providing even more support to customers amid inflation and rising costs.

Spire continues to provide multiple programs for those with higher energy burdens, including:

- DollarHelp

- Payment Arrangements

- LIHEAP

- Customer Charge Waiver Program

- Payment Partner Program

- Critical Medical Needs

- Budget Billing

Customers who are struggling are encouraged to contact Spire or its community partners to learn more about options by calling 211 or visiting spireenergy.com/assistance.

About Spire

At Spire (NYSE: SR), our vision is to deliver a stronger energy future as an industry-leading natural gas provider. We safely and reliably serve the natural gas needs of close to 2 million homes and businesses through gas utilities in Alabama, Mississippi, Missouri and Tennessee, making us one of the largest publicly traded natural gas companies in the country. We are committed to transforming our business through growing organically, investing in infrastructure and driving continuous improvement. Learn more at SpireEnergy.com.

Investor Contact:

Megan L. McPhail

314-309-6563

[email protected]

Media Contact:

Jason Merrill

314-342-3300

[email protected]

SOURCE Spire Inc.

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<p>ST. LOUIS, Nov. 2, 2026 /PRNewswire/ -- Today, Spire Missouri filed a rate case with the Missouri Public Service Commission (PSC) to support continued investments in its natural gas system that enhance safety, reliability and service for customers. "Our focus is on safely and reliably...</p>

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Kölner Polizeipräsident verteidigt Vorgehen der Polizei
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Kölner Polizeipräsident verteidigt Vorgehen der Polizei

Köln (ots)

Der Kölner Polizeipräsident Johannes Hermanns hat im WDR das Vorgehen der Polizei bei den Jugendprotesten am Wochenende verteidigt. Im Interview mit der Lokalzeit Köln sagte Hermanns, es seien ganz viele junge Leute da gewesen, die friedlich waren.

„Aber frühzeitig haben schon aus unserer Sicht extremistische Kräfte diese jungen Menschen unterlaufen, unterwandert. Wir hatten auch einen Block schwarz gekleideter Menschen, die sich relativ früh in die Versammlung eingeschlichen hatten. Da haben wir dann auch diese Waffen (geschliffene Messer und Stichwerkzeuge) festgestellt und die haben dann von vornherein für eine unfriedliche Stimmung gesorgt. Wir hatten relativ früh schon Raketenschüsse, Steinwürfe in der Versammlung und deswegen hat es am Ende auch dazu geführt, dass wir die Versammlung nicht mehr durch die Stadt haben ziehen lassen.“

Die Lage sei im Laufe der Nacht noch extremer geworden, sagte Hermanns weiter.

„Und im weiteren Verlauf der Nacht, bei den Krawallen, die wir in der Stadt hatten, waren unsere Polizeikräfte schon massiven Angriffen ausgesetzt. Dieser Polizeihelm (zeigt auf einen beschädigten Helm vor sich), der ist beschädigt worden durch einen Pflastersteinwurf, der mittig ins Visier getroffen hat. Der Helm, der hat unseren Kollegen natürlich geschützt. Aber daran kann man sehen, mit welcher Gewalt hier vorgegangen wird. Und das ist nach meinem Dafürhalten schon nicht mehr nur Körperverletzungen, sondern das sind schon Attacken, die sich auf das Leben unserer jungen Kollegen richten.“

Pressekontakt:

WDR Newsroom

Svenja Böhnisch

0221 220 8182

Original-Content von: WDR Newsroom, übermittelt durch news aktuell

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WDR Newsroom: Köln (ots) - Der Kölner Polizeipräsident Johannes Hermanns hat im WDR das Vorgehen der Polizei bei den Jugendprotesten am Wochenende verteidigt. Im Interview mit der Lokalzeit Köln sagte Hermanns, es seien ganz viele junge Leute da gewesen, die ...

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CHRISTMAS WONDERLAND RETURNS TO TROPICAL PARK NOV. 12 WITH A MILE OF SYNCHRONIZED MUSIC AND LIGHTING SPECTACULAR, THE 230-FOOT AMERICA 250 WHEEL, AND A NEW CLASSIC EUROPEAN-STYLE CHRISTMAS MARKET
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Miami's Favorite Holiday Tradition Marks Its Fourth Season With Light Up the Night, an Hourly Light and Music Spectacular Along the Mile-Long Tinsel Trail, Plus Duck Discovery, Holiday Harmonies Choir Nights, Six Themed Holiday Worlds, More Than 50 Unlimited Carnival Rides, and Food and Drinks From Miami's Favorite Local Vendors

MIAMI, Nov. 2, 2026 /PRNewswire/ -- For generations of South Florida families, the first sign of Christmas was the glow of lights through the trees at Tropical Park, spotted from the back seat on the drive down the Palmetto Expressway. This season, Christmas Wonderland at Tropical Park carries that hometown tradition into its fourth year from Thursday, Nov. 12, 2026, through Sunday, Jan. 3, 2027. Produced by Loud And Live, the Miami-based entertainment company behind many of the region's large-scale events, the 14-acre celebration debuts the 230-foot America 250 Wheel, a classic European-style Christmas market, and new experiences for families, all set along a mile of lights synchronized to music.

Christmas Wonderland pairs the nostalgia Miami's grown-ups remember with a polished, modern holiday night out built for today's families, couples and friends. Guests will find immersive themed worlds designed by award-winning creative teams, more than 50 unlimited carnival rides, hundreds of photo moments, craft cocktails and coquito, seasonal brews, and a lineup of Miami's favorite local food vendors. Every ride, show, and attraction is included with a single admission ticket.

"Miami grew up celebrating Christmas at Tropical Park, and our job is to give the next generation a version of that tradition worth passing down," said Tony Albelo, President of Loud And Live Events. "This year we invested in the details guests feel the moment they walk in, from a light show choreographed to music every hour, to a Christmas market inspired by the fabulous holiday markets of Europe. It is the kind of night families, couples, and friends will want to make part of their season every year."

LIGHT UP THE NIGHT: A MILE OF LIGHTS, CHOREOGRAPHED TO MUSIC

At the heart of Christmas Wonderland is Tinsel Trail, a mile of lights that winds through all six of the park's holiday worlds. What drivers glimpse from the Palmetto is only a preview. Every hour on the hour, the entire mile-long trail comes together for Light Up the Night, a synchronized light and music spectacular in which every archway, display, and installation along the route moves in time to a holiday soundtrack. The show travels through the themes of the trail, from the Miami color of HoliDade to the frosty hush of Arctic Delight, and builds to a parkwide finale in the European-style new marketplace.

Guests will reach for their phones, and many will find themselves lowering them to take in the moment with the people beside them. Light Up the Night is included with admission and runs every hour, every night of the season.

NEW FOR 2026

- America 250 Wheel: Rising 230 feet above Tropical Park, the America 250 Wheel is billed as the world's largest portable observation wheel and was built to celebrate the nation's 250th anniversary. Each of its 45 gondolas honors one of the 45 U.S. presidents and shares historical facts with riders, while views from the top stretch up to 14 miles. The 700,000-pound wheel arrives on 11 tractor-trailers. Rides are included with paid admission.

- Christmas Marketplace: The Christmas Marketplace makes its debut as a brand-new addition to Tinsel Trail, bringing the spirit of Europe's bespoke Christmas markets to Tropical Park. Twinkling chalets and picturesque photo moments surround the park's towering Christmas tree, where artisans and local Miami vendors offer holiday classics like handcrafted ornaments and seasonal treats. Guests can warm up and get cozy with hot cocoa from a toppings bar and spiced cider, roasted nuts, and an array of delicatessen delights, all while enjoying classic Christmas carols and visits from St. Nicholas.

- Duck Discovery: Complimentary for children 12 and younger, this parkwide hunt follows a flock of 24 festive rubber ducks that have waddled away from the North Pole. Kids pick up a Duck Passport at the entrance, register at the Duck Depot, and search Tinsel Trail for the four to five varieties hidden each night, earning a dated stamp for every new find. Collect 10 different ducks to earn a four-pack of tickets for a return visit, or find all 24 to win a grand prize for the 2027 season. A daily "Today's Flock" sign at the entrance and on social media shows which ducks are out each night.

- Holiday Harmonies: On Choir Nights, Dec. 1, 8, and 15, local choirs fill the park with carols, and each evening closes with a song the whole crowd sings together.

- Santa's Enchanted Forest Memory Lane: A tribute along Tinsel Trail to the holiday tradition South Florida families grew up with at Tropical Park, Memory Lane brings back original set pieces, classic photo spots including Surfin' Santa, and the signature jingle generations of Miamians still know by heart.

SIX THEMED HOLIDAY WORLDS

Tinsel Trail connects six themed worlds, each with its own look, photo moments, and surprises:

HoliDade, presented by Estrella Insurance: A tribute to the people, culture, and neighborhoods of Miami-Dade County, with more than 12 photo installations designed by award-winning Moyano Productions, the creative team behind the Museum of Ice Cream. Highlights include the Gingerbread Lifeguard Stand, a sugar-frosted nod to Miami Beach, and the Toy Factoria, a twinkling ode to Hialeah.

Town Square: A storybook hometown setting with twinkling lights, festive storefronts, and classic holiday décor, plus Tony's Tree Farm and a vintage Christmas truck ready for its close-up.

Sweet Street, presented by Amanda Demanda: Sweet Street transforms into a vibrant landscape of candy canes, gingerbread, and holiday confections. The themed area features whimsical décor and family-friendly photo moments, with on-site safety reminders and holiday tips from this year's returning sponsor, Amanda Demanda, underscoring the firm's commitment to community well-being during the season.

Toy Town: Oversized toys, Santa's Elf Brigade, kid-sized rides including the Kids Wheel, and a Letters to Santa station where children can send their wishes to the North Pole.

Arctic Delight: Guests step through a wall of snow into a frosty winter scene. Adults can raise a glass at Nelson's Nightcap Bar, presented by XXL Wines, pouring wine, Champagne, seasonal cocktails, and ready-to-drink cans.

Santa's Village: At the end of the trail, Santa welcomes guests to the North Pole among the reindeer stables and busy elf workshops. Professional commemorative photos with Santa are available for an additional fee, with advance booking recommended.

RIDES, FOOD, AND DRINK

Beyond the trail, The Magnificent Midway delivers more than 50 rides, from three roller coasters and high-energy thrill rides to family favorites such as the carousel and bumper cars, all included with admission.

Food and drink are part of the night. Some of South Florida's favorite food trucks and local vendors serve holiday sweets, local specialties, and carnival classics, while festive bars pour coquito, craft cocktails, and seasonal beverages throughout the park. XXL Wines presents Nelson's Nightcap Bar in Arctic Delight, pouring wine, Champagne, ready-to-drink mixed drinks, and more, while CervecerÃa La Tropical returns as the official beer partner with refreshing seasonal brews.

Christmas Wonderland also welcomes back several valued partners, including FPL, Presenting Partner of the Opening Ceremony; Ford, Official Truck Partner; Goya; Club Travalia and Florida Blue, whose continued support helps bring the holiday magic to life.

THEME NIGHTS

Special programming fills the calendar throughout the season:

DATES AND HOURS

Season: Thursday, Nov. 12, 2026, through Sunday, Jan. 3, 2027

Location: Tropical Park, 7900 SW 40th St., Miami, FL 33155

Extended hours: Gates open at 4 p.m. daily Nov. 23 to 28 (Thanksgiving week) and Dec. 21 to Jan. 2 (winter break).

Closed: Monday, Nov. 16; Monday, Nov. 30; and Monday, Dec. 7

TICKETS AND PARKING

Admission includes unlimited rides, the America 250 Wheel, live shows, Light Up the Night, photo opportunities, and Santa encounters. Carnival games, food, beverages, merchandise, and professional photos with Santa are additional.

Weekday Online Bundle Deals are available in limited quantities online until 5 p.m. on the day of admission, plus taxes and fees. Blackout dates apply.

Parking: Free on-site parking, with VIP parking available for purchase. Free trolley service runs from the main lots until one hour after closing.

Tickets and information: MiamiWonderland.com

Follow Christmas Wonderland on social media:

- Instagram: @ChristmasWonderlandMIA

- Facebook: facebook.com/ChristmasWonderlandMIA

- TikTok: @christmaswonderlandmiami

- YouTube: @ChristmasWonderlandMiami

ABOUT LOUD AND LIVE:

Loud And Live, is an entertainment, marketing, media and live events company, merging music, sports, lifestyle and content development. Headquartered in Miami with a presence across the U.S., Puerto Rico, Europe, and Latin America, Loud And Live is driven by its passion in creating engaging experiences for global audiences www.loudlive.com

SOURCE Loud and Live, Inc.

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<p>Miami's Favorite Holiday Tradition Marks Its Fourth Season With Light Up the Night, an Hourly Light and Music Spectacular Along the Mile-Long Tinsel Trail, Plus Duck Discovery, Holiday Harmonies Choir Nights, Six Themed Holiday Worlds, More Than 50 Unlimited Carnival Rides, and Food and...</p>

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REI Co-op Continues to Opt Outside on Black Friday
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On Friday, Nov. 27, the specialty outdoor retailer will once again give 12,000 employees a paid day off, inviting millions of members to trade shopping lines for time outdoors.

SEATTLE, Nov. 2, 2026 /PRNewswire/ -- REI Co-op will once again close its doors on Black Friday, continuing a tradition that began more than a decade ago. This year, we're reminding everyone there's no wrong way to Opt Outside. Whether it's a hike, a walk around the neighborhood, a picnic in the park or simply stepping outside for some fresh air, as long as you're out there, it counts.

Since its launch in 2015, Opt Outside has inspired millions of people and hundreds of organizations to rethink how they spend Black Friday. What began as an invitation to skip the shopping crowds has become a celebration of the many ways time outdoors brings people together. In 2022, REI made the annual closure permanent, ensuring employees would continue to have the day off each year.

On Nov. 27, all REI stores, distribution centers, call centers and headquarters will be closed. Customers can continue to browse and place orders online, with order processing and fulfillment resuming the following day.

To find inspiration for spending time outside, visit REI.com/opt-outside.

About the REI Co-op

REI is a specialty outdoor retailer, headquartered near Seattle. The nation's largest consumer co-op, REI is a growing community of 26 million members who expect and love the best quality gear and outstanding customer service. In addition to the co-op's many stores across the country, outdoor enthusiasts can shop at REI.com, REI Outlet or the REI shopping app. Everyone is welcome to shop REI, but members who join the co-op enjoy a range of benefits. REI is a purpose-driven and values-led company dedicated to enabling life outside for all.

SOURCE REI (Recreational Equipment, Inc.)

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<p>On Friday, Nov. 27, the specialty outdoor retailer will once again give 12,000 employees a paid day off, inviting millions of members to trade shopping lines for time outdoors. SEATTLE, Nov. 2, 2026 /PRNewswire/ -- REI Co-op will once again close its doors on Black Friday, continuing a...</p>

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Maya Mobile named Best Global Roaming Services at the TripZilla Excellence Awards 2026
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Voted by the travel community, the travel eSIM brand takes the top spot in the 12th edition of the awards.

MIAMI, Nov. 2, 2026 /PRNewswire/ -- Maya Mobile, the travel eSIM with unlimited data plans in 165+ countries, has been named the winner of Best Global Roaming Services at the TripZilla Excellence Awards 2026. The result follows an extensive round of public voting, with only one winner crowned in each category.

Now in its 12th edition, the TripZilla Excellence Awards recognize the brands that set the standard for travel across the region. The awards are backed by TripZilla, a leading travel media platform reaching over 20 million travelers every month.

"This award was decided by travelers, which is exactly why it matters to us," said Maya Mobile Executive. "People want to land, switch on, and get on with their trip. One eSIM, unlimited data, and a plan for every trip length. That is what the travel community voted for."

The win reflects a growing shift among international travelers toward travel eSIMs as an alternative to traditional carrier roaming.

Why travelers choose Maya Mobile

- Global coverage: 165+ countries, with 5G in most destinations.

- Unlimited data plans: 3, 7, 14, or 30 days, from $9.99, or $1.67/day on the 30-day plan.

- One eSIM, installed once: add a new plan for every trip directly in the app.

- Trusted by travelers: 3.5M+ users and a 4.6-star Trustpilot rating from 12,000+ reviews.

- Built for every traveler: eSIMs for the whole family managed from one Maya account.

- 24/7 Support: real help, in any time zone.

The full list of winners is published on the TripZilla Excellence Awards 2026 website.

About Maya Mobile

Maya Mobile is a travel eSIM provider offering unlimited data plans in 165+ countries through a single eSIM. Travelers install Maya once, then add 3, 7, 14 or 30-day plans as they go, from $1.67/day. More than 3.5M travelers use Maya Mobile, rated 4.5 stars on Trustpilot. Live Life Unlimited. Learn more at maya.net.

SOURCE Maya Mobile

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<p>Voted by the travel community, the travel eSIM brand takes the top spot in the 12th edition of the awards. MIAMI, Nov. 2, 2026 /PRNewswire/ -- Maya Mobile, the travel eSIM with unlimited data plans in 165+ countries, has been named the winner of Best Global Roaming Services at the...</p>

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