Ultima Genomics Major Sequencing Award for Singapore's National Precision Medicine (NPM) Program Phase III
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Ultima Genomics Major Sequencing Award for Singapore's National Precision Medicine (NPM) Program Phase III

- Marks Ultima's first major win to support a national-scale clinical whole genome sequencing initiative

- NPM Phase III will leverage Ultima's UG200 Platform and recent advancements that enable large-scale applications, including Solaris 2.0 Chemistry, launched in February 2026.

- Ultima will partner with Lucence, a leading Singapore-based clinical lab offering clinical and oncology applications, and QIAGEN, the leader in technologies enabling end-to-end clinical sequencing workflows

SINGAPORE and FREMONT, Calif., Nov. 2, 2026 /PRNewswire/ -- Ultima Genomics, a company offering a new architecture for enabling ultra-high-throughput next generation sequencing, today announced that its UG200 Sequencing Platform has been selected for the SG-INSIGHT study, a cohort under Phase III of Singapore's National Precision Medicine (NPM) program, a national initiative focused on advancing the integration of genomics into clinical workflows and healthcare delivery. Precision Health Research, Singapore (PRECISE) is the central coordinating office for the NPM program. The award coincides with recent advancements in Ultima's technology that enable high-quality, large-scale, and low-cost whole genome sequencing, including the launch of Ultima's UG200 Sequencing Platform and Solaris 2.0 chemistry in February 2026. Ultima will support the program through a collaboration with Singapore-based Lucence, a Singapore-based precision medicine leader, and QIAGEN, a global leader in Sample to Insight solutions.

NPM Phase III significantly expands the scale and scope of Singapore's precision medicine effort to about 450,000 individuals â nearly one in 10 Singapore residents â with a significant shift toward participants receiving medical treatment and healthcare services. Unlike Phase II, which focused on healthy individuals, Phase III includes patients across a wide spectrum of health conditions from Singapore's three public healthcare clusters: NHG Health, National University Health System (NUHS) and SingHealth. NPM Phase III is intended to generate evidence to support the safe and effective rollout of genetic screening and future integration of genomics into public healthcare.

The selection of Ultima technology as part of the Consortium led by Lucence follows an extensive evaluation process. Throughout the process, Ultima and its consortium partners demonstrated a comprehensive approach that addressed quality, clinical readiness, pricing and innovation using Ultima's latest technology, including the UG200 system, Solaris 2.0 chemistry, and bioinformatics analytics.

"This award is an important milestone for Ultima Genomics and demonstrates significant advancements to our platform that unlock whole genome sequencing for clinical applications at scale, at low cost, and with high-quality data. NPM Phase III's SG-INSIGHT cohort is an excellent example of how Ultima's drive towards lower costs can support national-scale precision medicine initiatives across geographies worldwide. It also shows how the UG200 can enable our customers and partners to support cost-sensitive initiatives," said Gilad Almogy, Chief Executive Officer of Ultima Genomics. "We are honored to work alongside Lucence and QIAGEN in Singapore and to contribute to a program that is advancing the integration of genomics into healthcare. NPM Phase III's SG-INSIGHT represents an important opportunity to demonstrate how innovation, collaboration, and operational excellence can accelerate precision medicine at a population scale."

Under the collaboration, Lucence will provide end-to-end clinical program management and local operational leadership, QIAGEN will support sample preparation and automation workflows, and Ultima will provide sequencing and genomic analysis capabilities designed to enable high-quality, scalable, clinical-grade whole-genome sequencing. Together, the consortium aims to support the successful execution of NPM Phase III and to establish a model for future national genomics initiatives.

The award further strengthens Ultima's presence in the Asia-Pacific region and underscores the company's ongoing commitment to advancing population genomics, precision medicine, oncology, rare disease research, and emerging clinical applications across global healthcare systems. SG-INSIGHT is expected to serve as a key reference program as governments, healthcare providers, and research institutions explore broader adoption of precision medicine.

Singapore has established itself as a global leader in biomedical innovation and precision medicine. Through collaboration with local healthcare, research, and industry partners, Ultima aims to contribute to the development of a sustainable genomics ecosystem that supports scientific advancement, clinical innovation, and long-term healthcare impact.

Ultima continues to advance its sequencing and analysis capabilities to support clinical whole genome sequencing at population scale. These efforts include the recent launch of paired-end sequencing and the development of pangenome-aware WGS analysis, which is expected to be available by year-end 2026. Together, these capabilities will expand the flexibility of Ultima's technology for whole-genome and other large-scale sequencing applications.

https://www.ultimagenomics.com/

About Ultima Genomics

Ultima Genomics is unleashing the power of genomics at scale. The Company's mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in human health. With humanity on the cusp of a biological revolution, there is a virtually endless need for more genomic information to address biology's complexity and dynamic changeâand a further need to challenge conventional next-generation sequencing technologies. Ultima's revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists and clinicians are forced to make between the breadth, depth and frequency with which they use genomic information. The new sequencing architecture was designed to scale far beyond conventional sequencing technologies, lower the cost of genomic information, and catalyze the next phase of genomics in the 21st century. To learn more, visit www.ultimagenomics.com.

About Precision Health Research, Singapore (PRECISE)

Precision Health Research, Singapore (PRECISE) leads the National Precision Medicine (NPM) programme, advancing genomics to improve health and grow Singapore's biomedical sector. Phase II sequenced 100,000 Singaporeans, while Phase III, in partnership with Singapore's three healthcare clusters, is evaluating how genomics can be integrated into clinical care responsibly.

PRECISE is a programme of the Consortium for Clinical Research and Innovation, Singapore (CRIS). NPM Phase II is supported by the National Research Foundation, Singapore under the White Space funding (MOH-000588 and MOH-001264) and administered by the Singapore Ministry of Health (MOH) through the National Medical Research Council (NMRC) Office, MOH Holdings Pte Ltd. NPM Phase III is supported by the Singapore MOH through the NMRC Office, MOH Holdings Pte Ltd under the NMRC NPM Phase III Funding Initiative (MOH-001734).

Forward-Looking Statements

This press release contains forward-looking statements, including statements regarding anticipated benefits from participation in Singapore's National Precision Medicine Program, the expected impact of the NPM Phase III initiative, future sequencing volumes and program expansion opportunities, advancement of precision medicine, growth opportunities in Asia-Pacific and other regions, development of future collaborations, and potential clinical and commercial applications of Ultima's technologies. These forward-looking statements are based on current expectations and assumptions and involve risks and uncertainties that could cause actual results to differ materially from those expressed or implied. Factors that may affect actual results include program timelines, regulatory developments, market conditions, clinical validation outcomes, operational execution, technological performance, and other risks associated with the commercialization and adoption of genomic technologies. Ultima Genomics undertakes no obligation to update forward-looking statements except as required by applicable law.

Media Contact

Vikki Herrera

Oak Street Communications for Ultima Genomics

[email protected]

408-206-7009

SOURCE Ultima Genomics

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<p>Marks Ultima's first major win to support a national-scale clinical whole genome sequencing initiative NPM Phase III will leverage Ultima's UG200 Platform and recent advancements that enable large-scale applications, including Solaris 2.0 Chemistry, launched in February 2026. Ultima will...</p>

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West Tennessee Banker Kirk Goehring Receives National Emerging Leader Award
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West Tennessee Banker Kirk Goehring Receives National Emerging Leader Award

WASHINGTON, Nov. 2, 2026 /PRNewswire/ -- West Tennessee banker Kirk M. Goehring, chief executive officer of Decatur County Bank, has earned national recognition as one of 11 recipients of the American Bankers Association's 2026 Emerging Leader Awards, which honor outstanding leadership, professional achievement and community service in the banking industry.

The annual awards recognize the next generation of banking professionals who demonstrate high standards of achievement and service to both the industry and their local communities. Goehring was selected through a competitive, multi-round review process conducted by banking industry professionals who evaluated nominations submitted from across the country.

"I'm honored to be recognized as an emerging leader in an industry that I love, and receiving this from the American Bankers Association makes it especially meaningful. This award belongs to our entire team at Decatur County Bank and West Tennessee Bank, whose commitment to our communities and clients shows every day," Goehring said.

Jay England, chairman of the bank's board of directors, praised Goehring's leadership and the relationships he has built throughout Jackson and West Tennessee.

"Kirk is a natural leader, and has shown in his life as an athlete, coach, banker and as a church and community leader how important it is to bring people together. This Bank has grown and furthered our mission of serving the people of the community, due to Kirk's leadership, commitment and love of the folks in Jackson and West Tennessee."

The ABA Emerging Leader Awards recognize banking professionals who demonstrate dedication to their profession, innovative thinking, leadership skills, mentoring ability, personal integrity and sustained career growth. The selection committee also considers nominees' commitment to a long-term career in banking, professional experience and academic training.

"The talent and dedication of this year's ABA Emerging Leaders reflect a passion for innovation, a commitment to excellence and a willingness to lead by example," said Rob Nichols, ABA president and CEO. "We congratulate this outstanding group on this well-deserved recognition and look forward to the contributions they will make to our industry and the communities they serve."

Goehring and the other members of the ABA Emerging Leader Awards Class of 2026 were recognized during the ABA Annual Convention, held in October in Salt Lake City, Utah.

Learn more about each member of the ABA's Class of 2026.

About Decatur County Bank

Founded in 1899, Decatur County Bank has always prioritized understanding and fulfilling the aspirations of its patrons. It currently operates branches in Parsons, Decaturville and Jackson. As a division of Decatur County Bank, it continues to strengthen its community ties.

For more information about West Tennessee Bank, visit westtnbank.com. Member FDIC.

About the American Bankers Association

The American Bankers Association represents the nation's $26.5 trillion banking industry, which includes small, regional and large banks employing more than 2 million people, safeguarding $20.7 trillion in deposits and extending $13.9 trillion in loans.

SOURCE West Tennessee Bank / Decatur County Bank

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<p>WASHINGTON, Nov. 2, 2026 /PRNewswire/ -- West Tennessee banker Kirk M. Goehring, chief executive officer of Decatur County Bank, has earned national recognition as one of 11 recipients of the American Bankers Association's 2026 Emerging Leader Awards, which honor outstanding leadership,...</p>

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SiriusXM Pays Tribute to Hip-Hop Icons Wu-Tang Clan with Launch of The Wu-Tang Clan Channel Presented by Rock The Bells Radio
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SiriusXM Pays Tribute to Hip-Hop Icons Wu-Tang Clan with Launch of The Wu-Tang Clan Channel Presented by Rock The Bells Radio

The Wu-Tang Clan Channel debuts November 4, celebrating the group's legendary music, cultural influence, and enduring legacy

NEW YORK, NY – November 2, 2026 – SiriusXM today announced the launch of The Wu-Tang Clan Channel presented by Rock The Bells Radio, an exclusive pop-up channel celebrating one of hip-hop's most influential groups and their lasting impact on music and culture.

The channel will be available to subscribers on the SiriusXM app from November 4 through December 1.

The Wu-Tang Clan Channel takes listeners deep into the Wu-Tang universe, featuring classic anthems, essential album cuts, iconic solo projects, and live performances. Fans will also hear exclusive interviews with Wu-Tang Clan members, rare stories behind the music, and special programming available only on SiriusXM.

The celebration extends to LL COOL J's Rock The Bells Radio, SiriusXM channel 43, where every Wednesday in November will be dedicated to all things Wu-Tang. These special Wu-Wednesdays will spotlight the group's more than three-decade career with music from their legendary catalog, exclusive commentary, behind-the-scenes insights, and personal reflections on the collective's influence and legacy.

Members of Wu-Tang Clan will also sit down in front of a live audience at SiriusXM’s Los Angeles studios for an exclusive Front Row Q&A event hosted by Peter Rosenberg on Thursday, November 12. The full conversation will air Friday, November 13 at 6pm ET on both LL COOL J’s Rock The Bells Radio and The Wu-Tang Clan Channel and will be available afterwards on the SiriusXM app. In celebration of the pop-up channel, SiriusXM subscribers and fans can enter for a chance to win a pair of tickets to attend a special Front Row with Wu-Tang Clan. Click HERE for full details.

The Wu-Tang Channel presented by Rock the Bells Radio is a month-long celebration of one of hip-hop's most influential groups, as they celebrate Wu-Tang Clan Day in New York City honoring the release date of their 1993 landmark debut album and are inducted into the Rock & Roll Hall Of Fame.

Eligible customers can get their first three months of SiriusXM for free. Click here to sign up and experience all that SiriusXM has to offer. See Offer Details.

###

About Wu-Tang Clan

Founded in New York City's Staten Island in the early 1990s, the Rock & Roll Hall of Fame inductees-elect Wu-Tang Clan comprises members RZA, GZA, Method Man, Raekwon, Ghostface Killah, U-God, Masta Killa, Inspectah Deck, Cappadonna, and the late Ol' Dirty Bastard (ODB).

Led by the production of RZA, samples from martial arts films have thematically appeared throughout the group's music, as have samples including Kung Fu films’ classical strings alongside soul legends like Isaac Hayes, Syl Johnson, James Brown and Rick James.

With a slew of gold and platinum releases, Wu-Tang Clan’s collective catalog spans over 85 LPs. More than just rappers, Wu-Tang Clan are entrepreneurs and successful cultural influencers, with an empire that features everything from clothing lines and video games to books and acting credits.

Considered by many to be the greatest hip-hop group of all time, Wu-Tang Clan have been touring as a unit since their debut record- Enter the Wu-Tang (36 Chambers)- came out in 1993. The now quadruple-platinum release vaulted the New York City group with songs like "C.R.E.A.M." (Cash Rules Everything Around Me) and "Protect Ya Neck" that are about as recognizable as anything in the rap canon.

Whether they're headlining their global farewell tour, Wu-Tang Forever: The Final Chamber or bringing tracks from GZA's seminal Liquid Swords and Raekwon's mafioso-minded Only Built 4 Cuban Linx…, while honoring the legacy of their departed brother, Ol' Dirty Bastard on stages worldwide, every Wu-Tang Clan show is a celebration of prolific careers as individuals and especially as the most storied group in hip-hop history.

About Sirius XM Holdings Inc.

SiriusXM is the leading audio entertainment company in North America, with a portfolio of audio businesses including its flagship subscription entertainment service SiriusXM; the ad-supported and premium music streaming services of Pandora; an expansive podcast network; and a complete ecosystem of advertising solutions through SiriusXM Media and AdsWizz. SiriusXM offers live, on-demand, and human-curated programming across music, talk, news, sports, and podcasts, and the company reaches approximately 255 million monthly listeners across its platforms. With deep automotive manufacturer relationships and unique spectrum assets, SiriusXM is built to reach listeners wherever they are. The company connects fans to the voices, creators, and moments they love - creating communities where listeners engage, participate, and belong. For more about SiriusXM, please go to: https://www.siriusxm.com/

Source: SiriusXM

Media Contacts for SiriusXM:

Carolina Dubón

carolina.dubon@siriusxm.com

Marley Gerber

Marley.gerber@siriusxm.com

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Leidos mobilizes supply chain to scale production of thousands of U.S. cruise missiles
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RESTON, Va., Nov. 2, 2026 /PRNewswire/ -- Leidos (NYSE: LDOS) is moving to strengthen the U.S. missile industrial base and prepare for production of thousands of affordable long-range cruise missiles, bringing together key missile-component suppliers to develop and scale production of its new Low-Cost Containerized Missile (LCCM) and the combat-proven AGM-190A Havoc Spear missile.

The summit, held September 26 at Leidos' global headquarters, aligned industry partners on requirements, manufacturing capacity, timelines and delivery schedules. That work supports the May 13 framework agreement between the Department of War and Leidos for an initial 3,000 LCCM weapons, which is expected to advance the nation's long-range strike capacity. It also supports the combat-proven AGM-190A Havoc Spear cruise missile, as initial deliveries to Air Force Special Operations Command are now underway.

Leidos perspective: "The nationwide Leidos cruise missile supply chain team is putting in place the robust plans and resources that'll allow us quickly scale cruise missile production," said Leidos Defense President Cindy Gruensfelder. "We're investing in our people, facilities, and supply chain to deliver proven capability to warfighters with a real sense of urgency."

Scaling for America's security:

- Industrial capacity: Leidos' LCCM and AGM-190A production work will primarily be in Huntsville, Alabama, and McEwen, Tennessee. Its suppliers will do work in 14 states across the country.

What's next:

- LCCM: The first missiles are expected to be delivered in 2027 to support test and evaluation, with full-rate production anticipated in 2028 and 2029.

- AGM-190A Havoc Spear: Leidos has begun initial deliveries to Air Force Special Operations Command and received a summer 2026 contract award from U.S. Special Operations Command for 45 missiles, with deliveries under that award expected to begin in fall 2027.

Supplier perspectives:

- "Demand has never been higher, and our customers are counting on us to deliver dependable propulsion for today's operational fleets and future programs," said Jessica Villardi, vice president of Fighter and Mobility Programs at Pratt & Whitney. "Pratt & Whitney is investing in capacity and advanced manufacturing to strengthen the industrial base and accelerate delivery of the proven, dependable power our customers need."

- "I think this is going to be the new paradigm going forward in delivering capability to the Department of War," said Ben Nicholson, Chief Commercial Officer for Divergent. "After a more than 30-year career in D.C., I haven't seen a prime pull suppliers together like this, at pace, with genuine urgency, and share information the way things were done today."

The big picture: Leidos brings decades of experience designing and integrating missile systems, launchers and precision strike technology for the U.S. military. Its portfolio includes the Army's Indirect Fire Protection Capability Increment 2 (IFPC Inc 2) launcher, hypersonic strike technology and advanced guidance and sensor capabilities for air and missile defense.

About Leidos

Leidos is an industry and technology leader serving government and commercial customers with smarter, more efficient digital and mission innovations. Headquartered in Reston, Virginia, with approximately 50,000 global employees, Leidos reported annual revenues of approximately $17.2 billion for the fiscal year ended January 2, 2026. For more information, visit www.leidos.com.

Certain statements in this announcement constitute "forward-looking statements" within the meaning of the rules and regulations of the U.S. Securities and Exchange Commission (SEC). These statements are based on management's current beliefs and expectations and are subject to significant risks and uncertainties. These statements are not guarantees of future results or occurrences. A number of factors could cause our actual results, performance, achievements, or industry results to be different from the results, performance, or achievements expressed or implied by such forward-looking statements. These factors include, but are not limited to, the "Risk Factors" set forth in Leidos' Annual Report on Form 10-K for the fiscal year ended January 2, 2026, and other such filings that Leidos makes with the SEC from time to time. Readers are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date hereof. Leidos does not undertake to update forward-looking statements to reflect the impact of circumstances or events that arise after the date the forward-looking statements were made.

Media contact:

Philip Carder

(571) 926-6698

[email protected] 

SOURCE Leidos Holdings, Inc.

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<p>RESTON, Va., Nov. 2, 2026 /PRNewswire/ -- Leidos (NYSE: LDOS) is moving to strengthen the U.S. missile industrial base and prepare for production of thousands of affordable long-range cruise missiles, bringing together key missile-component suppliers to develop and scale production of its...</p>

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Majority of Patients with Moderate Aortic Stenosis Carry Features Linked to Twice the Risk of Death, egnite Registry Study Finds
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The analysis, published simultaneously in JACC, found that moderate AS patients with at least one at-risk feature had a two-fold increase in mortality and hospitalization with heart failure compared with moderate AS patients with no at-risk features over two years.

Dr. Philippe Généreux also announced ACTIVATE AS, the first prospective multicenter study to use the CardioCare® platform to identify and follow patients with moderate AS.

SAN DIEGO, Nov. 2, 2026 /PRNewswire/ -- In a real-world study of more than 53,000 patients with aortic stenosis (AS) at 48 U.S. institutions, moderate AS outnumbered severe AS nearly 2 to 1, and 78.7% of patients with moderate AS had at least one at-risk feature. Over two years, those patients had twice the rate of mortality and hospitalization with heart failure as moderate AS patients without at-risk features, according to data presented today by Philippe Généreux, MD, Director, Structural Heart Program at Atlantic Health Morristown Medical Center, at TCT 2026 San Diego and published simultaneously in the Journal of the American College of Cardiology (JACC).

The study analyzed de-identified data from the egnite Registry, covering nearly 15 million patients and 6.5 million echocardiograms with appropriate permissions, making it the largest study of moderate AS outcomes to date.

Dr. Généreux also announced ACTIVATE AS, a prospective, multicenter study that will use the CardioCare platform to identify approximately 700 patients with moderate AS and follow them rigorously in a dedicated valve clinic with multiparametric evaluation every six months. It is the first prospective clinical study to use CardioCare, with enrollment expected to begin in 2027.

Key findings

Among 53,994 patients with moderate or severe AS identified since January 2022:

- Moderate AS outnumbered severe AS nearly 2 to 1 in this cohort (35,343 vs. 18,651 patients). Of the moderate patients, 78.7% had at least one at-risk feature: valve-related symptoms, left ventricular ejection fraction below 60%, grade 2 or higher diastolic dysfunction, low stroke volume index, atrial fibrillation, or elevated natriuretic peptides. Excluding symptoms, 69.9% still had at least one at-risk feature.

- At-risk features were associated with double the risk of death and hospitalization with heart failure. Two-year mortality was 20.1% for moderate AS patients with at-risk features vs. 9.0% without. Hospitalization with heart failure was 44.6% vs. 21.9%. After multivariable adjustment, including for comorbidities, at-risk features remained associated with roughly twice the risk of death and hospitalization with heart failure.

- Most events occurred while patients were still labeled as moderate. On the last echocardiogram before the event, 86% of hospitalizations with heart failure and 90% of deaths among moderate AS patients occurred while still moderate, without evidence of progression to severe AS.

Current ACC/AHA guidelines recommend echocardiographic surveillance every one to two years for moderate AS, with valve replacement deferred until severe criteria are met. In the study, 20% to 23% of moderate AS patients underwent valve replacement documented by the contributing health system within two years, compared with 50.1% of patients with severe AS.

ACTIVATE AS prospective study

ACTIVATE AS (Activating Patients with Moderate AS) is a prospective, multicenter, observational study of patients with moderate AS. Atlantic Health Morristown Medical Center will serve as the lead site and coordinating center, and enrollment is expected to begin in 2027.

The study will use the CardioCare platform to identify approximately 700 patients with moderate AS across participating sites, grouped by disease phenotype. Patients will be recalled for heart team evaluation, including echocardiography assessed by a core laboratory, natriuretic peptide testing and CT aortic valve calcium scoring. Patients in the study will be followed every six months for up to two years or until they develop severe AS or undergo an aortic valve replacement. ACTIVATE AS is an investigator-initiated study led by Dr. Généreux and funded by an unrestricted grant from Edwards Lifesciences.

"This is CardioCare's first use in a prospective, multicenter study to identify and follow patients, building on the egnite Registry," said Rahul Sharma, MBBS, FRACP, Director of Structural Interventions and Associate Director of the Cardiac Catheterization Laboratory at Stanford Health Care, Senior Medical Advisor of egnite, and co-author of the Moderate Aortic Stenosis with At-risk Features study. "The Registry identifies where risk concentrates in moderate AS; ACTIVATE AS will evaluate these patients in clinical practice through structured assessments and six-month follow-up. Over time, this evidence could help guide monitoring intervals for patients with moderate AS."

About the study

The analysis used de-identified EHR and echocardiographic data from the egnite Registry, covering 14,859,523 patients and 6,514,171 echocardiograms at 48 U.S. institutions with appropriate permissions. It included adults diagnosed with native-valve moderate or severe AS on or after Jan. 1, 2022, and received exemption from Institutional Review Board review. The full manuscript, "Moderate Aortic Stenosis with At-risk Features," is available in JACC.

AS severity was graded from quantitative valve measurements in echocardiography reports according to American Society of Echocardiography guidelines. The analysis was supported by a study grant from Edwards Lifesciences. Findings are observational; full methods and limitations are available in the JACC publication.

About egnite, Inc.

egnite, Inc. is a technology company advancing guideline-directed cardiovascular care and real-world evidence. egnite's CardioCare® platform is deployed at more than 80 heart programs, drawing on data from more than 1,200 cardiovascular care facilities, to identify and prioritize cardiovascular patients. CardioCare combines practical AI, clinical logic aligned to ACC/AHA guidelines and workflow integration to help hospitals move more patients into evidence-based care pathways. The egnite Registry, built on de-identified EHR data with appropriate permissions from 15.7 million patients and 6 million echo reports, gives life sciences and research teams a longitudinal view of the patient journey. The company is headquartered in Aliso Viejo, California. For more information, visit www.egnitehealth.com.

SOURCE egnite Health

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<p>The analysis, published simultaneously in JACC, found that moderate AS patients with at least one at-risk feature had a two-fold increase in mortality and hospitalization with heart failure compared with moderate AS patients with no at-risk features over two years. Dr. Philippe Généreux...</p>

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{"target_audience": "b2b", "is_medical": true, "ai_generated_title": "Moderate AS Patients With Risk Features Show Double Mortality", "body_html": "<p><strong>SAN DIEGO -- [CURRENT_DATE] --</strong> Moderate aortic stenosis (AS) patients with at least one at-risk feature had twice the two-year rate of death and heart failure hospitalization as moderate AS patients without such features, according to a real-world study of 53,994 patients at 48 U.S. institutions. Philippe Généreux, MD, Director of the Structural Heart Program at Atlantic Health Morristown Medical Center, presented the data at TCT 2026 San Diego. The analysis was published simultaneously in the Journal of the American College of Cardiology (JACC).</p><h5>Moderate AS outnumbers severe AS nearly 2 to 1 in the cohort</h5><p>The cohort comprised 35,343 moderate and 18,651 severe AS patients diagnosed on or after Jan. 1, 2022. Of the moderate patients, 78.7% had at least one at-risk feature. The features were valve-related symptoms, left ventricular ejection fraction below 60%, grade 2 or higher diastolic dysfunction, low stroke volume index, atrial fibrillation, or elevated natriuretic peptides. Excluding symptoms, 69.9% still had at least one.</p><h5>Two-year mortality reaches 20.1% with at-risk features versus 9.0% without</h5><p>Hospitalization with heart failure was 44.6% in moderate patients with at-risk features versus 21.9% in those without. After multivariable adjustment, including for comorbidities, at-risk features remained associated with roughly twice the risk of both outcomes.</p><p>Most events occurred before any documented progression. On the last echocardiogram before the event, 86% of heart failure hospitalizations and 90% of deaths among moderate AS patients occurred while the patient was still classed as moderate.</p><h5>Valve replacement rates for moderate AS patients stay at 20% to 23%</h5><p>Current ACC/AHA guidelines call for echocardiographic surveillance every one to two years in moderate AS, with valve replacement deferred until severe criteria are met. Within two years, 20% to 23% of moderate AS patients underwent valve replacement documented by the contributing health system, compared with 50.1% of severe AS patients.</p><h5>egnite Registry data covers 14,859,523 patients and 6,514,171 echocardiograms</h5><p>The study used de-identified EHR and echocardiographic data from the egnite Registry, which the source describes as the largest study of moderate AS outcomes to date. AS severity was graded from quantitative echocardiography measurements under American Society of Echocardiography guidelines. The study received an exemption from Institutional Review Board review and was supported by a study grant from Edwards Lifesciences. The findings are observational.</p><h5>ACTIVATE AS will enroll about 700 moderate AS patients from 2027</h5><p>Généreux also announced ACTIVATE AS (Activating Patients with Moderate AS), a prospective, multicenter, observational study. It is the first prospective clinical study to use egnite's CardioCare platform. The platform will identify roughly 700 moderate AS patients across participating sites and group them by disease phenotype. Atlantic Health Morristown Medical Center will serve as lead site and coordinating center, and enrollment is expected to begin in 2027.</p><p>Patients will be recalled for heart team evaluation, including echocardiography assessed by a core laboratory, natriuretic peptide testing and CT aortic valve calcium scoring. They will be followed every six months for up to two years, or until they develop severe AS or undergo aortic valve replacement. The investigator-initiated study is funded by an unrestricted grant from Edwards Lifesciences.</p><p>Rahul Sharma, MBBS, FRACP, of Stanford Health Care, a Senior Medical Advisor of egnite and co-author of the JACC paper, said the registry identifies where risk concentrates in moderate AS, while \"ACTIVATE AS will evaluate these patients in clinical practice.\" He said the evidence could help guide monitoring intervals.</p><p>CardioCare is deployed at more than 80 heart programs.</p>", "meta_description": "Study of 53,994 aortic stenosis patients finds 78.7% with moderate disease carry at-risk features, doubling two-year mortality; ACTIVATE AS trial starts 2027.", "seo_keywords": "aortic stenosis, moderate AS, egnite Registry, CardioCare, ACTIVATE AS, TCT 2026, JACC, Edwards Lifesciences, heart failure hospitalization, structural heart", "companies": ["egnite", "Edwards Lifesciences", "Atlantic Health Morristown Medical Center"], "industries": ["Healthcare & Biotech"], "markets_regions": ["United States"], "news_type": ["research_publication", "clinical_study_announcement"], "products": ["CardioCare"], "themes": ["real_world_evidence", "cardiovascular_care", "clinical_research"], "events": ["TCT 2026"], "cta_text": "Learn more about egnite's CardioCare platform and egnite Registry", "learn_more": "https://www.egnitehealth.com", "fact_check": {"accuracy_score": 98, "legal_risk": "low", "corrections_made": ["Corrected garbled character encoding in physician name", "Used [CURRENT_DATE] placeholder in dateline per instructions"], "recommendation": "publish"}}
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Camect and 3Si: Strategic Partnership to Bring AI-Powered Video Intelligence Directly to Public Safety
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New integration connects Camect's intelligent video detection and 3Si's DirectToDispatch⢠platform, delivering actionable incident intelligence to public safety when every second counts.

MOUNTAIN VIEW, Calif., Nov. 2, 2026 /PRNewswire/ -- Camect, an innovator in AI-powered video intelligence and intelligent security camera technology, today announced a strategic technology partnership with 3Si Security Systems, a trusted provider of security intelligence solutions for public safety and private-sector organizations.

The partnership connects Camect's advanced AI-powered video intelligence with 3Si's award-winning DirectToDispatch⢠platform, creating a more direct pathway between intelligent security detection and public safety response.

By combining Camect's ability to identify relevant activity across existing security camera systems and 3Si's established public safety intelligence network, the companies are working together to transform how critical incident information reaches the people responsible for protecting communities. Request a demo today to see Camect's powerful capabilties first hand!

Connecting Video Intelligence to Public Safety Response

Across businesses, commercial properties, and communities, security cameras capture enormous amounts of video every day. However, identifying meaningful activity and turning that information into actionable intelligence remains a challenge.

Camect's AI-powered video analysis addresses this challenge by detecting relevant activity, minimizing unnecessary alerts, and providing meaningful visual context. Through the partnership with 3Si, Camect intelligence can extend beyond traditional security monitoring into public safety workflows.

3Si's DirectToDispatch⢠platform creates a connection between private-sector security intelligence and public safety agencies, supporting the delivery of actionable incident information when it matters most.

Together, Camect and 3Si aim to help bridge the gap between detecting an incident and enabling a more informed response.

"This integration with 3Si empowers our dealers and the communities they serve to maintain control of their video data while securely sharing relevant information with the people who need it most: our first responders," said Ron Grubbs, VP of Sales Business Development at Camect. "3Si has been a trusted partner in public safety for decades, and we are incredibly proud to work alongside them to help strengthen community safety and support those on the front lines."

From intelligent detection to actionable dispatch intelligence, Camect and 3Si share a vision of a future where security technology doesn't simply capture what happens, it helps the right people understand and respond to it.

About Camect

Camect is a Silicon Valley-based technology company specializing in AI-powered video intelligence and advanced security camera solutions. Designed to make existing camera systems smarter, Camect transforms ordinary security cameras into intelligent tools capable of identifying meaningful activity with over 40 advanced detections and features, reducing false alerts, and delivering actionable video insights in real time.

With a camera-agnostic approach, privacy-focused architecture, and support for professional monitoring, Real-Time Crime Centers (RTCCs), and Emergency Communications Centers (ECCs), Camect helps businesses, security professionals, and public safety organizations gain greater value from their existing video infrastructure with over 30 integrations and growing.

Headquartered in Mountain View, California, Camect is committed to making intelligent video security more accessible, connected, and effective.

Request a demo today of Camect's advanced detections and features, visit Camect.com

Learn more about this integration visit www.camect.com.

About 3Si Security Systems

3Si is a leading provider of innovative security solutions, dedicated to creating a safer, more secure world. The company combines technology with real-world experience to deliver an intelligent platform that protects people, assets, and law enforcement while enabling informed, real-time decision-making.

With relationships spanning more than 10,400 law enforcement agencies, 3Si delivers actionable crime intelligence directly to police dispatch for crime prioritization and response. Its integrated technology portfolio includes covert GPS tracking, camera and video solutions, video management technology, and its award-winning DirectToDispatch⢠platform.

From detection to dispatch, every second counts.

Learn more at www.3sisecurity.com

CONTACT:

David Leon | [email protected]

SOURCE Camect

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<p>New integration connects Camect's intelligent video detection and 3Si's DirectToDispatch™ platform, delivering actionable incident intelligence to public safety when every second counts. MOUNTAIN VIEW, Calif., Nov. 2, 2026 /PRNewswire/ -- Camect, an innovator in AI-powered video...</p>

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Notice of Data Event
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EAST LONGMEADOW, Mass., Nov. 2, 2026 /PRNewswire/ -- Magnolia Management Company, LLC ("Magnolia") is providing notice of a recent data privacy event that may have affected limited protected health information for certain individuals. On April 3, 2026, Magnolia became aware of unauthorized activity in one employee email account. Upon discovery, Magnolia took immediate action to secure its email environment and investigate the scope of the event, including hiring a third-party forensic investigation firm. Following a thorough review, Magnolia confirmed that a limited amount of information may have been accessed by an unauthorized individual. Magnolia undertook a comprehensive review of the impacted data to identify what type of information was contained therein, and to whom that information belonged. On August 10, 2026, that review was completed.

In response to this event, Magnolia also implemented additional technical safeguards to further enhance the security of information in its possession and with the aim of preventing similar events from happening in the future. While there is no evidence of actual or attempted misuse of any information as a result of this event, Magnolia will be providing impacted individuals with access to complimentary credit monitoring and identity protection services.

Magnolia takes the confidentiality of information in its care very seriously and regrets any inconvenience or concern caused by this event. If you have any questions, please call our dedicated assistance line at 833-918-4065, Monday â Friday, 8 am â 8 pm CT, excluding major U.S. holidays.

Individuals are encouraged to remain vigilant against events of identity theft by reviewing credit reports, account statements, and explanation of benefits forms for suspicious activity and to detect errors.

Individuals may place a fraud alert or credit freeze by contacting the credit reporting agencies: TransUnion 1-800-680-7289, P.O. Box 2000 Chester, PA 19016, transunion.com; Experian 1-888-397-3742, P.O. Box 9554 Allen, TX 75013, experian.com; Equifax 1-888-298-0045, P.O. Box 105069 Atlanta, GA 30348, equifax.com.

Individuals can further educate themselves regarding identity theft, fraud alerts, credit freezes, and steps to protect their personal information by contacting the credit reporting bureaus, the Federal Trade Commission, or their state attorney general. The FTC may be reached at 600 Pennsylvania Ave. NW, Washington, D.C. 20580; www.identitytheft.gov; 1-877-ID-THEFT (1- 877-438-4338); and TTY: 1-866-653-4261. Instances of known or suspected identity theft should also be reported to law enforcement, your state attorney general, and the FTC.

SOURCE Magnolia Management Company, LLC

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<p>EAST LONGMEADOW, Mass., Nov. 2, 2026 /PRNewswire/ -- Magnolia Management Company, LLC ("Magnolia") is providing notice of a recent data privacy event that may have affected limited protected health information for certain individuals. On April 3, 2026, Magnolia became aware of...</p>

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Rosen Law Firm Encourages NVE Corporation Investors to Inquire About Securities Class Action Investigation - NVEC
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NEW YORK, Nov. 2, 2026 /PRNewswire/ --

Why: Rosen Law Firm, a global investor rights law firm, announces an investigation of potential securities claims on behalf of shareholders of NVE Corporation (NASDAQ: NVEC) resulting from allegations that NVE Corporation may have issued materially misleading business information to the investing public.

So What: If you purchased NVE Corporation securities you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. The Rosen Law Firm is preparing a class action seeking recovery of investor losses.

What to do next: To join the prospective class action, go to https://www.rosenlegal.com/cases/nve-corporation/join or call Phillip Kim, Esq. toll-free at 866-767-3653 or email [email protected] for information on the class action.

What is this about: Rosen Law Firm is investigating potential civil securities claims.

Why Rosen Law: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered billions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the-rosen-law-firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

Contact Information:

     Laurence Rosen, Esq.

Phillip Kim, Esq.

The Rosen Law Firm, P.A.

275 Madison Avenue, 40th Floor

New York, NY 10016

Tel: (212) 686-1060

Toll Free: (866) 767-3653

Fax: (212) 202-3827

[email protected]

www.rosenlegal.com

SOURCE THE ROSEN LAW FIRM, P. A.

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<p>NEW YORK, Nov. 2, 2026 /PRNewswire/ -- Why: Rosen Law Firm, a global investor rights law firm, announces an investigation of potential securities claims on behalf of shareholders of NVE Corporation (NASDAQ: NVEC) resulting from allegations that NVE Corporation may have issued materially...</p>

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Men's Clothing Experts Tom Napoli & Rico Marotto Discuss How to Choose Between a Suit & Tuxedo in HelloNation
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The article explores how wedding dress codes, venues, and personal style influence the choice between suits and tuxedos.

KEY HIGHLIGHTS

- A tuxedo is traditionally more formal than a suit, with distinctive satin or grosgrain details that make it appropriate for black-tie weddings.

- Wedding dress codes, venue settings, and time of day help determine whether a suit or tuxedo is appropriate.

- Proper fit, fabric selection, and coordinated accessories contribute to a polished appearance for grooms and wedding guests.

BUFFALO, N.Y., Nov. 2, 2026 /PRNewswire/ -- Should you wear a suit or a tuxedo to a wedding?

HelloNation has published an article providing the answer, featuring insights from Tom Napoli and Rico Marotto, Men's Clothing Experts of Napoli's Clothing & Shoes in Buffalo, NY. The article explains how the wedding dress code, venue, and level of formality help determine the most appropriate attire for grooms and guests.

What Is the Difference Between a Wedding Suit and a Tuxedo?

The HelloNation article explains that a tuxedo is traditionally considered the more formal option. It typically features satin or grosgrain details on the lapels, buttons, and trouser seams, often paired with a formal shirt and bow tie.

A wedding suit generally offers greater versatility. Suits typically feature matching jackets and trousers without contrasting trim and can be styled with different ties, pocket squares, and accessories.

The article notes that choosing between wedding suits and tuxedos depends primarily on the occasion's formality rather than personal preference alone.

How Does the Wedding Dress Code Affect Your Choice?

The article identifies the wedding dress code as the most important consideration when selecting an outfit. Black-tie weddings traditionally require tuxedos, especially for evening celebrations.

Black-tie optional events allow greater flexibility, with either a tuxedo or a dark, formal suit generally considered appropriate.

Cocktail attire typically calls for a well-tailored suit in navy, charcoal, or black. Semi-formal wedding attire may allow additional flexibility depending on the setting and season.

The article emphasizes that following the invitation's stated expectations helps guests avoid appearing overdressed or underdressed.

How Do the Venue and Time of Day Influence Wedding Attire?

The HelloNation article explains that formal wedding attire may vary depending on the venue. Ballrooms and upscale hotels often complement traditional formalwear, while gardens, vineyards, and outdoor settings may support a more relaxed appearance.

Evening celebrations are commonly associated with darker suits and tuxedos. Daytime weddings often favor suits in lighter colors or fabrics.

However, the article notes that the stated dress code should take priority over assumptions based on the venue.

What Should Grooms Consider When Choosing Wedding Attire?

The article explains that grooms should consider how their clothing complements the wedding party's overall appearance. Coordinating fabrics, colors, and accessories can create a consistent look.

Matching outfits are one option, but subtle differences can distinguish the groom from the groomsmen without disrupting the overall style.

Whether selecting cocktail attire or semi-formal wedding attire, coordination helps maintain a polished appearance.

Why Are Fit and Fabric Important for Wedding Clothing?

The HelloNation article explains that properly fitted wedding suits and tuxedos should have well-positioned shoulders, appropriate sleeve lengths, and trousers that drape cleanly.

Fabric selection also affects comfort. Lightweight wool and breathable blends may suit warmer conditions, while heavier materials provide structure during cooler months.

Tom Napoli and Rico Marotto, Men's Clothing Experts of Napoli's Clothing & Shoes in Buffalo, NY, provide insights emphasizing why fit, comfort, and the wedding dress code should guide formal wedding attire decisions.

Suit or Tuxedo: How to Choose the Right Wedding Attire features insights from Tom Napoli and Rico Marotto, Men's Clothing Experts of Buffalo, NY, in HelloNation.

FREQUENTLY ASKED QUESTIONS

What Is the Main Difference Between a Suit and a Tuxedo?

According to Tom Napoli and Rico Marotto, Men's Clothing Experts of Buffalo, NY, tuxedos typically feature satin or grosgrain trim and are associated with more formal occasions. Suits offer greater styling versatility.

Do Black-Tie Weddings Require a Tuxedo?

Tom Napoli and Rico Marotto explain through the HelloNation article that black-tie weddings traditionally call for tuxedos. Black-tie optional invitations generally allow either a tuxedo or a dark, formal suit.

What Should Guests Wear for Cocktail Attire?

Based on insights from Tom Napoli and Rico Marotto, Men's Clothing Experts of Buffalo, NY, cocktail attire generally calls for a well-tailored suit. Navy, charcoal, and black are common choices.

Can a Groom Wear a Different Outfit Than the Groomsmen?

The HelloNation article explains that grooms can distinguish their outfits through coordinated accessories or subtle color variations. Maintaining a consistent overall appearance helps create a cohesive wedding party.

How Important Is Tailoring for Wedding Attire?

According to Tom Napoli and Rico Marotto, Men's Clothing Experts of Buffalo, NY, proper tailoring improves the appearance of both suits and tuxedos. Shoulder fit, sleeve length, and trouser drape are important considerations.

About HelloNation

HelloNation is America's Good News Network, a premier media platform built on the idea that good news travels faster when real people tell real stories. Through its community-focused publications and innovative "edvertising" approach, HelloNation delivers content that informs, inspires, and spotlights the leaders making a meaningful impact in their communities.

SOURCE HelloNation

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Consumer-focused guidance on choosing wedding suits and tuxedos, with useful product and styling information.
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<p>The article explores how wedding dress codes, venues, and personal style influence the choice between suits and tuxedos. KEY HIGHLIGHTS A tuxedo is traditionally more formal than a suit, with distinctive satin or grosgrain details that make it appropriate for black-tie weddings. Wedding...</p>

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AAR prices offering of $955 million of 7.125% senior notes due 2031 and $960 million of 7.375% senior notes due 2034
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WOOD DALE, Ill., Nov. 2, 2026 /PRNewswire/ -- AAR CORP. ("AAR" or the "Company") (NYSE: AIR), the leading parts, repair, and software platform in the aviation aftermarket, announced today that it has successfully priced its offering (the "offering") of $955 million aggregate principal amount of 7.125% senior notes due 2031 (the "2031 Notes") and $960 million aggregate principal amount of 7.375% senior notes due 2034 (the "2034 Notes" and, together with the 2031 Notes, the "Notes"). The 2031 Notes will bear interest at a fixed annual rate of 7.125% and will mature on November 15, 2031, and the 2034 Notes will bear interest at a fixed annual rate of 7.375% and will mature on November 15, 2034. The offering is expected to close on November 17, 2026, subject to customary closing conditions.

The Company intends to use the net proceeds from the offering, together with the net proceeds from its previously announced private placement of an aggregate of 2,215,791 shares of the Company's common stock, par value $1.00 per share and borrowings under its revolving credit facility (the "Amended Revolving Credit Facility"), to (i) pay the cash consideration for the Company's previously announced pending acquisition (the "MRO Holdings Acquisition") of a controlling interest in MRO Holdings, Inc. ("MRO Holdings"), (ii) fund an intercompany term loan to MRO Holdings (the "Intercompany Loan"), the proceeds of which will be used to repay, prepay, redeem, defease, discharge, or otherwise refinance in full all outstanding indebtedness under MRO Holdings' existing credit agreement and to terminate all commitments thereunder and release all guarantees and liens securing the obligations thereunder, (iii) pay any premiums, fees, and expenses incurred in connection with the MRO Holdings Acquisition and the financing transactions related thereto, and (iv) fund working capital and other general corporate purposes. In addition, the Company will issue equity with an agreed value of approximately $780.8 million as partial consideration for the MRO Holdings Acquisition.

If the offering closes prior to the consummation of the MRO Holdings Acquisition, (1) the gross proceeds from the offering of each series of Notes (less the initial purchasers' discounts and commissions) will be deposited into a segregated escrow account (collectively, the "Escrow Accounts") for the benefit of the holders of the applicable series of Notes until the date on which certain escrow conditions are satisfied in connection with the closing of the MRO Holdings Acquisition, and (2) each series of Notes will be subject to a special mandatory redemption at a price equal to the initial issue price of the applicable series of Notes, plus accrued and unpaid interest from the issue date of such series of Notes to, but excluding, the date of the special mandatory redemption. If the offering closes substantially concurrently with the consummation of the MRO Holdings Acquisition, the Notes will not be subject to the aforementioned procedures.

Prior to the consummation of the MRO Holdings Acquisition and the release of proceeds from the Escrow Accounts, if applicable, the Notes will not be guaranteed. From and after the consummation of the MRO Holdings Acquisition and the release of such proceeds, if applicable, or on the issue date of the Notes if the MRO Holdings Acquisition closes substantially concurrently with the offering, the Notes will be fully and unconditionally guaranteed, on a joint and several basis, by each of the Company's present and future wholly owned domestic subsidiaries that guarantee the Company's obligations under the Amended Revolving Credit Facility, subject to certain exceptions.

The Notes and the related guarantees have not been and will not be registered under the Securities Act of 1933, as amended (the "Securities Act"), any state securities laws or the securities laws of any other jurisdiction. The Notes and the related guarantees may not be offered or sold in the United States or to, or for the benefit of, U.S. persons absent registration or pursuant to an exemption from, or in a transaction not subject to, registration. The Notes and related guarantees will be offered and sold only to persons reasonably believed to be "qualified institutional buyers" in accordance with Rule 144A under the Securities Act and to certain non-U.S. persons in offshore transactions in reliance on Regulation S under the Securities Act.

This press release is neither an offer to sell, nor the solicitation of an offer to buy, the Notes or any other securities and shall not constitute an offer to sell or a solicitation of an offer to buy, or a sale of, the Notes or any other securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful.

About AAR

AAR is a leading global aerospace and defense aftermarket solutions company with operations in over 20 countries. Headquartered in the Chicago area, AAR supports commercial and government customers through three primary operating segments: Parts Supply; Repair, Engineering, and Software; and Government Solutions.

Contact

Chris Tillett â Investor Relations

+1-630-227-5830

[email protected] 

SOURCE AAR CORP.

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<p>WOOD DALE, Ill., Nov. 2, 2026 /PRNewswire/ -- AAR CORP. ("AAR" or the "Company") (NYSE: AIR), the leading parts, repair, and software platform in the aviation aftermarket, announced today that it has successfully priced its offering (the "offering") of $955 million aggregate principal...</p>

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